2qcd: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
[[Image:2qcd.jpg|left|200px]]<br /><applet load="2qcd" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2qcd.jpg|left|200px]]
caption="2qcd, resolution 2.03&Aring;" />
 
'''Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase bound to UMP'''<br />
{{Structure
|PDB= 2qcd |SIZE=350|CAPTION= <scene name='initialview01'>2qcd</scene>, resolution 2.03&Aring;
|SITE= <scene name='pdbsite=AC1:U5p+Binding+Site+For+Residue+A+1'>AC1</scene>, <scene name='pdbsite=AC2:U5p+Binding+Site+For+Residue+B+2'>AC2</scene> and <scene name='pdbsite=AC3:S+Binding+Site+For+Residue+A+481'>AC3</scene>
|LIGAND= <scene name='pdbligand=U5P:URIDINE-5'-MONOPHOSPHATE'>U5P</scene> and <scene name='pdbligand=S:SULFUR ATOM'>S</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23]
|GENE= UMPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase bound to UMP'''
 


==Overview==
==Overview==
Line 10: Line 19:


==About this Structure==
==About this Structure==
2QCD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=U5P:'>U5P</scene> and <scene name='pdbligand=S:'>S</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] Known structural/functional Sites: <scene name='pdbsite=AC1:U5p+Binding+Site+For+Residue+A+1'>AC1</scene>, <scene name='pdbsite=AC2:U5p+Binding+Site+For+Residue+B+2'>AC2</scene> and <scene name='pdbsite=AC3:S+Binding+Site+For+Residue+A+481'>AC3</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QCD OCA].  
2QCD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QCD OCA].  


==Reference==
==Reference==
Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design., Wittmann JG, Heinrich D, Gasow K, Frey A, Diederichsen U, Rudolph MG, Structure. 2008 Jan;16(1):82-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18184586 18184586]
Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design., Wittmann JG, Heinrich D, Gasow K, Frey A, Diederichsen U, Rudolph MG, Structure. 2008 Jan;16(1):82-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18184586 18184586]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Orotidine-5'-phosphate decarboxylase]]
[[Category: Orotidine-5'-phosphate decarboxylase]]
Line 26: Line 35:
[[Category: ump synthase]]
[[Category: ump synthase]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:38:10 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:24:23 2008''
Retrieved from "https://proteopedia.org/2qcd"