2qfi: Difference between revisions
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[[Image:2qfi.gif|left|200px]] | [[Image:2qfi.gif|left|200px]] | ||
'''Structure of the zinc transporter YiiP''' | {{Structure | ||
|PDB= 2qfi |SIZE=350|CAPTION= <scene name='initialview01'>2qfi</scene>, resolution 3.80Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | |||
|ACTIVITY= | |||
|GENE= fieF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]) | |||
}} | |||
'''Structure of the zinc transporter YiiP''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2QFI is a [ | 2QFI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QFI OCA]. | ||
==Reference== | ==Reference== | ||
Structure of the zinc transporter YiiP., Lu M, Fu D, Science. 2007 Sep 21;317(5845):1746-8. Epub 2007 Aug 23. PMID:[http:// | Structure of the zinc transporter YiiP., Lu M, Fu D, Science. 2007 Sep 21;317(5845):1746-8. Epub 2007 Aug 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17717154 17717154] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: zinc transporter]] | [[Category: zinc transporter]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:25:23 2008'' | ||
Revision as of 16:25, 20 March 2008
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| 2qfi, resolution 3.80Å | |||||||||||||
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| Ligands: | ZN | ||||||||||||
| Gene: | fieF (Escherichia coli) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Structure of the zinc transporter YiiP
Overview
YiiP is a membrane transporter that catalyzes Zn2+/H+ exchange across the inner membrane of Escherichia coli. Mammalian homologs of YiiP play critical roles in zinc homeostasis and cell signaling. Here, we report the x-ray structure of YiiP in complex with zinc at 3.8 angstrom resolution. YiiP is a homodimer held together in a parallel orientation through four Zn2+ ions at the interface of the cytoplasmic domains, whereas the two transmembrane domains swing out to yield a Y-shaped structure. In each protomer, the cytoplasmic domain adopts a metallochaperone-like protein fold; the transmembrane domain features a bundle of six transmembrane helices and a tetrahedral Zn2+ binding site located in a cavity that is open to both the membrane outer leaflet and the periplasm.
About this Structure
2QFI is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Structure of the zinc transporter YiiP., Lu M, Fu D, Science. 2007 Sep 21;317(5845):1746-8. Epub 2007 Aug 23. PMID:17717154
Page seeded by OCA on Thu Mar 20 18:25:23 2008
