2mh3: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
m Protected "2mh3" [edit=sysop:move=sysop]
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
'''Unreleased structure'''
{{STRUCTURE_2mh3|  PDB=2mh3  |  SCENE=  }}
===NMR structure of the basic helix-loop-helix region of the transcriptional repressor HES-1===
{{ABSTRACT_PUBMED_24403087}}


The entry 2mh3 is ON HOLD
==Function==
[[http://www.uniprot.org/uniprot/HES1_HUMAN HES1_HUMAN]] Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.<ref>PMID:18550849</ref> 


Authors: Wienk, H., Popovic, M., Coglievina, M., Boelens, R., Pongor, S., Pintar, A.
==About this Structure==
[[2mh3]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MH3 OCA].  


Description: NMR structure of the basic helix-loop-helix region of the transcriptional repressor HES-1
==Reference==
<ref group="xtra">PMID:024403087</ref><references group="xtra"/><references/>
[[Category: Boelens, R.]]
[[Category: Coglievina, M.]]
[[Category: Pintar, A.]]
[[Category: Pongor, S.]]
[[Category: Popovic, M.]]
[[Category: Wienk, H.]]
[[Category: Bhlh]]
[[Category: Dna binding protein]]
Retrieved from "https://proteopedia.org/2mh3"