4btu: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4btu|  PDB=4btu  |  SCENE=  }}
===factor Xa in complex with the dual thrombin-FXa inhibitor 57.===
{{ABSTRACT_PUBMED_24175584}}


The entry 4btu is ON HOLD until Paper Publication
==Disease==
[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[http://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>  


Authors: Meneyrol, J., Follmann, M., Lassalle, G., Wehner, V., Barre, G., Rousseaux, T., Altenburger, J.M., Petit, F., Bocskei, Z., Stehlin-Gaon, C., Schreuder, H., Alet, N., Herault, J.-P., Millet, L., Dol, F., Hasbrand, C., Schaeffer, P., Sadoun, F., Klieber, S., Briot, C., Bono, F., Herbert, J.-M.
==Function==
[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.  


Description: factor Xa in complex with the dual thrombin-FXa inhibitor 57.
==About this Structure==
[[4btu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BTU OCA].
 
==Reference==
<ref group="xtra">PMID:024175584</ref><references group="xtra"/><references/>
[[Category: Coagulation factor Xa]]
[[Category: Homo sapiens]]
[[Category: Alet, N.]]
[[Category: Altenburger, J M.]]
[[Category: Barre, G.]]
[[Category: Bocskei, Z.]]
[[Category: Bono, F.]]
[[Category: Briot, C.]]
[[Category: Dol, F.]]
[[Category: Follmann, M.]]
[[Category: Hasbrand, C.]]
[[Category: Herault, J P.]]
[[Category: Herbert, J M.]]
[[Category: Klieber, S.]]
[[Category: Lassalle, G.]]
[[Category: Meneyrol, J.]]
[[Category: Millet, L.]]
[[Category: Petit, F.]]
[[Category: Rousseaux, T.]]
[[Category: Sadoun, F.]]
[[Category: Schaeffer, P.]]
[[Category: Schreuder, H.]]
[[Category: Stehlin-Gaon, C.]]
[[Category: Wehner, V.]]
[[Category: Chlorothiophene p1 fragment]]
[[Category: Dual inhibitor]]
[[Category: Factor xa inhibitor]]
[[Category: Hydrolase]]
[[Category: Iv antithrombotic]]
[[Category: Microsomes stability]]
[[Category: Oral antithrombotic]]
[[Category: S3 subsite]]
[[Category: Sar107375]]
[[Category: Thrombin inhibitor]]
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