4nfn: Difference between revisions

Revision as of 11:37, 5 February 2014

[TTBK1_HUMAN] Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.^[1]

4nfn is a 1 chain structure. Full crystallographic information is available from OCA.

↑ Sato S, Cerny RL, Buescher JL, Ikezu T. Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. J Neurochem. 2006 Sep;98(5):1573-84. PMID:16923168 doi:JNC4059

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-'''Unreleased structure'''
+{{STRUCTURE_4nfn|  PDB=4nfn  |  SCENE=  }}
+===Human tau tubulin kinase 1 (TTBK1) complexed with 3-({5-[(4-amino-4-methylpiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-5-bromophenol===
-The entry 4nfn is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/TTBK1_HUMAN TTBK1_HUMAN]] Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.<ref>PMID:16923168</ref>
-Authors: Sheriff, S.
+==About this Structure==
+[[4nfn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NFN OCA].
-Description: Human tau tubulin kinase 1 (TTBK1) complexed with 3-({5-[(4-amino-4-methylpiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-5-bromophenol
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Sheriff, S.]]
+[[Category: Phosphotransferase]]
+[[Category: Protein kinase]]
+[[Category: Transferase-transferase inhibitor complex]]