4ni7: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of human interleukin 6 in complex with a modified nucleotide aptamer (SOMAMER SL1025)===

~~The~~ entry ~~4ni7~~ is ~~ON HOLD until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.

~~Authors~~: ~~Davies, D~~.~~, Edwards~~, T., ~~Gelinas~~, A.~~, Jarvis, T~~.~~, Clifton, M~~.

==Function==

[[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.

~~Description~~: ~~Crystal structure of human interleukin~~ 6 ~~in complex with a modified nucleotide aptamer (SOMAMER SL1025)~~

==About this Structure==

[[4ni7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NI7 OCA].

[[Category: Clifton, M.]]

[[Category: Davies, D.]]

[[Category: Edwards, T.]]

[[Category: Gelinas, A.]]

[[Category: Jarvis, T.]]

[[Category: Cytokine-dna complex]]

[[Category: Interleukin-6]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4ni7|  PDB=4ni7  |  SCENE=  }}
+===Crystal structure of human interleukin 6 in complex with a modified nucleotide aptamer (SOMAMER SL1025)===
-The entry 4ni7 is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.  Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
-Authors: Davies, D., Edwards, T., Gelinas, A., Jarvis, T., Clifton, M.
+==Function==
+[[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
-Description: Crystal structure of human interleukin 6 in complex with a modified nucleotide aptamer (SOMAMER SL1025)
+==About this Structure==
+[[4ni7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NI7 OCA].
+[[Category: Clifton, M.]]
+[[Category: Davies, D.]]
+[[Category: Edwards, T.]]
+[[Category: Gelinas, A.]]
+[[Category: Jarvis, T.]]
+[[Category: Cytokine-dna complex]]
+[[Category: Interleukin-6]]