SAGA-associated factor: Difference between revisions
Michal Harel (talk | contribs) New page: <StructureSection load='3mhs' size='350' side='right' caption='Structure of SGF11 in the SAGA complex with Sus1, SGF73 and UB8P (PDB entry 3mhs)' scene=''> '''SAGA-associated fact... |
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<StructureSection load='3mhs' size='350' side='right' caption='Structure of SGF11 (pink) in the SAGA complex with Sus1 (green) , SGF73 (magenta), ubiquitin (yellow) and UB8P (grey) (PDB entry [[3mhs]])' scene=''> | |||
<StructureSection load='3mhs' size='350' side='right' caption='Structure of SGF11 in the SAGA complex with Sus1, SGF73 and UB8P (PDB entry [[3mhs]])' scene=''> | |||
'''SAGA-associated factor''' (SGF) is part of the coactivator complex SAGA (Spt-Ada-Gcn5-Acetyl transferase) which facilitates transcription of stress-activated genes. SGF29 binds methylated lysine of histone H3 and is involved in transcriptional regulation. SGF11 is required for the deubiuqitination of histone H2B and for the maintenance of steady-state H3 methylation level. | '''SAGA-associated factor''' (SGF) is part of the coactivator complex SAGA (Spt-Ada-Gcn5-Acetyl transferase) which facilitates transcription of stress-activated genes. SGF29 binds methylated lysine of histone H3 and is involved in transcriptional regulation. SGF11 is required for the deubiuqitination of histone H2B and for the maintenance of steady-state H3 methylation level. | ||
==3D structures of SAGA-associated factor== | ==3D structures of SAGA-associated factor== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
===SGF11=== | ===SGF11=== | ||
[[2lo2]] – ySGF zinc finger domain – yeast – NMR<br /> | [[2lo2]] – ySGF zinc finger domain – yeast – NMR<br /> | ||
[3kik]], [[3kjl]] – ySGF Sus1-binding domain + Sus1 <br /> | [[3kik]], [[3kjl]] – ySGF Sus1-binding domain + Sus1 <br /> | ||
[[3mhh]], [[3m99]], [[4fip]], [[4fjc]], [[4fk5]] – yUBP8 + Sus1 +SGF73 - yeast<br /> | [[3mhh]], [[3m99]], [[4fip]], [[4fjc]], [[4fk5]] – yUBP8 + Sus1 +SGF73 - yeast<br /> | ||
[[3mhs]] – yUBP8 + Sus1 +SGF73 + ubiquitin<br /> | [[3mhs]] – yUBP8 + Sus1 +SGF73 + ubiquitin<br /> | ||
Revision as of 10:21, 27 November 2013
<StructureSection load='3mhs' size='350' side='right' caption='Structure of SGF11 (pink) in the SAGA complex with Sus1 (green) , SGF73 (magenta), ubiquitin (yellow) and UB8P (grey) (PDB entry 3mhs)' scene=>
SAGA-associated factor (SGF) is part of the coactivator complex SAGA (Spt-Ada-Gcn5-Acetyl transferase) which facilitates transcription of stress-activated genes. SGF29 binds methylated lysine of histone H3 and is involved in transcriptional regulation. SGF11 is required for the deubiuqitination of histone H2B and for the maintenance of steady-state H3 methylation level.
3D structures of SAGA-associated factor
Updated on 27-November-2013
SGF11
2lo2 – ySGF zinc finger domain – yeast – NMR
3kik, 3kjl – ySGF Sus1-binding domain + Sus1
3mhh, 3m99, 4fip, 4fjc, 4fk5 – yUBP8 + Sus1 +SGF73 - yeast
3mhs – yUBP8 + Sus1 +SGF73 + ubiquitin
SGF29
3me9, 3mea, 3met, 3meu, 3mev, 3mew, 3mp1, 3mp6 – hSGF tudor domain + histone H3 peptide – human
3lx7, 3mp8 - hSGF tudor domain
SGF73
2lo3 – ySGF zinc finger domain – NMR
