2m8a: Difference between revisions

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~~{{STRUCTURE_2m8a~~| ~~PDB~~=2m8a | ~~SCENE~~= }}

==2'F-ANA/2'F-RNA alternated sequences==

===2'F-~~ANA~~/2'F-~~RNA alternated sequences~~===

~~{{ABSTRACT_PUBMED_24115468}}~~

== Structural highlights ==

<table><tr><td colspan='2'>[[2m8a]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M8A FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AF2:2-DEOXY-2-FLUOROADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>AF2</scene>, <scene name='pdbligand=CFL:4-AMINO-1-(2-DEOXY-2-FLUORO-5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)PYRIMIDIN-2(1H)-ONE'>CFL</scene>, <scene name='pdbligand=CFZ:2-DEOXY-2-FLUOROCYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>CFZ</scene>, <scene name='pdbligand=GF2:2-DEOXY-2-FLUOROGUANOSINE+5-(DIHYDROGEN+PHOSPHATE)'>GF2</scene>, <scene name='pdbligand=TAF:2-DEOXY-2-FLUORO-ARABINO-FURANOSYL+THYMINE-5-PHOSPHATE'>TAF</scene>, <scene name='pdbligand=UFT:2-DEOXY-2-FLUOROURIDINE+5-(DIHYDROGEN+PHOSPHATE)'>UFT</scene></td></tr>

<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2m84|2m84]]</td></tr>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m8a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m8a RCSB], [http://www.ebi.ac.uk/pdbsum/2m8a PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

Polarizing CHO hydrogen bonds: The structure of oligonucleotides containing alternating and contiguous tracts of 2'F-RNA and 2'F-ANA nucleotides reveals that nonconventional FCHO hydrogen bonds have a strong stabilizing effect on 2'-fluorinated duplexes.

~~==About this Structure==~~

Backbone FCHO Hydrogen Bonds in 2'F-Substituted Nucleic Acids.,Martin-Pintado N, Deleavey GF, Portella G, Campos-Olivas R, Orozco M, Damha MJ, Gonzalez C Angew Chem Int Ed Engl. 2013 Sep 23. doi: 10.1002/anie.201305710. PMID:24115468<ref>PMID:24115468</ref>

~~[[2m8a]] is a~~ 2 ~~chain structure~~. ~~Full experimental information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il/oca-bin~~/~~ocashort?id=2M8A OCA].~~

==~~Reference~~==

From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>

~~<ref group="xtra">PMID:024115468</ref>~~<references ~~group="xtra"~~/><~~references~~/>

</div>

== References ==

__TOC__

</StructureSection>

[[Category: Campos, R.]]

[[Category: Damha, M.]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_2m8a|  PDB=2m8a  |  SCENE=  }}
+==2'F-ANA/2'F-RNA alternated sequences==
-===2'F-ANA/2'F-RNA alternated sequences===
+<StructureSection load='2m8a' size='340' side='right' caption='[[2m8a]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
-{{ABSTRACT_PUBMED_24115468}}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2m8a]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M8A FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AF2:2-DEOXY-2-FLUOROADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>AF2</scene>, <scene name='pdbligand=CFL:4-AMINO-1-(2-DEOXY-2-FLUORO-5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)PYRIMIDIN-2(1H)-ONE'>CFL</scene>, <scene name='pdbligand=CFZ:2-DEOXY-2-FLUOROCYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>CFZ</scene>, <scene name='pdbligand=GF2:2-DEOXY-2-FLUOROGUANOSINE+5-(DIHYDROGEN+PHOSPHATE)'>GF2</scene>, <scene name='pdbligand=TAF:2-DEOXY-2-FLUORO-ARABINO-FURANOSYL+THYMINE-5-PHOSPHATE'>TAF</scene>, <scene name='pdbligand=UFT:2-DEOXY-2-FLUOROURIDINE+5-(DIHYDROGEN+PHOSPHATE)'>UFT</scene></td></tr>
+<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2m84|2m84]]</td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m8a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m8a RCSB], [http://www.ebi.ac.uk/pdbsum/2m8a PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Polarizing CHO hydrogen bonds: The structure of oligonucleotides containing alternating and contiguous tracts of 2'F-RNA and 2'F-ANA nucleotides reveals that nonconventional FCHO hydrogen bonds have a strong stabilizing effect on 2'-fluorinated duplexes.
-==About this Structure==
+Backbone FCHO Hydrogen Bonds in 2'F-Substituted Nucleic Acids.,Martin-Pintado N, Deleavey GF, Portella G, Campos-Olivas R, Orozco M, Damha MJ, Gonzalez C Angew Chem Int Ed Engl. 2013 Sep 23. doi: 10.1002/anie.201305710. PMID:24115468<ref>PMID:24115468</ref>
-[[2m8a]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M8A OCA].
-==Reference==
+From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-<ref group="xtra">PMID:024115468</ref><references group="xtra"/><references/>
+</div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Campos, R.]]
 [[Category: Damha, M.]]