Sandbox Reserved 773: Difference between revisions
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'''Histidine Decarboxylase (HDC)''' is an enzyme that is responsible for biosynthesizing histamine from amino acid L-histidine. This enzyme belongs in the group II pyridoxal-5-phosphate (PLP)-dependent decarboxylase family [P19113, PF00282]. As the name suggested, this protein catalyze the production of histamine by the removal of carboxyl group from the amino acid L-histidine whilst utilize pyridoxal phosphate as an active-site cofactor [jbc]. The mammalian Histamine decarboxylase is originated from HDC gene which encodes a 74kDa polypeptide [3067, 1487235]. After post-translation process that truncates C-terminal of the HDC, the enzyme is around 54kDa [4e10, jbc]. | '''Histidine Decarboxylase (HDC)''' is an enzyme that is responsible for biosynthesizing histamine from amino acid L-histidine. This enzyme belongs in the group II pyridoxal-5-phosphate (PLP)-dependent decarboxylase family [P19113, PF00282]. As the name suggested, this protein catalyze the production of histamine by the removal of carboxyl group from the amino acid L-histidine whilst utilize pyridoxal phosphate as an active-site cofactor [jbc]. The mammalian Histamine decarboxylase is originated from HDC gene which encodes a 74kDa polypeptide [3067, 1487235]. After post-translation process that truncates C-terminal of the HDC, the enzyme is around 54kDa [4e10, jbc]. | ||
