Sandbox Reserved 773: Difference between revisions

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== Sequence and Structure ==

Histidine Decarboxylase is considered to be a homo-dimer when one observe its [[biological assembly]] <ref name=mast/>. A homodimer is a [[quaternary structure]] formed by two identical monomers or protein chains. In human, three human HDC (hHDC) homodimers can be joined together to form a trimer [[asymmetric unit]] <ref name=jbc/> <ref name=xray>PMID: 22684068</ref>. Thus, one can use the nomenclature “trimer of dimer” to suggest the complex might dissociate into smaller subunits before dissociating into monomers. The asymmetrical unit can be seen in Figure 1. Specifically, <scene name='56/564049/Cys180/1'>Cys-180</scene> and Cys-418 are primary responsible for the oligomerization process of HDC <ref name=xray/>.

Histidine Decarboxylase is considered to be a homo-dimer when one observe its [[biological assembly]] <ref name=mast/>. A homodimer is a [[quaternary structure]] formed by two identical monomers or protein chains. In human, three human HDC (hHDC) homodimers can be joined together to form a trimer [[asymmetric unit]] <ref name=jbc/> <ref name=xray>PMID: 22684068</ref>. Thus, one can use the nomenclature “trimer of dimer” to suggest the complex might dissociate into smaller subunits before dissociating into monomers. The asymmetrical unit can be seen in Figure 1. Specifically, <scene name='56/564049/Cys180/1'>Cys-180</scene> and <scene name='56/564049/Cys418/1'>Cys-418</scene> are primary responsible for the oligomerization process of HDC <ref name=xray/>.

Sandbox Reserved 773: Difference between revisions

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Revision as of 12:22, 2 December 2013 view source Wesley Yang (talk \| contribs) 185 edits →Sequence and Structure ← Older edit		Revision as of 12:30, 2 December 2013 view source Wesley Yang (talk \| contribs) 185 edits →Sequence and Structure Newer edit →
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	== Sequence and Structure ==		== Sequence and Structure ==

	Histidine Decarboxylase is considered to be a homo-dimer when one observe its [[biological assembly]] <ref name=mast/>. A homodimer is a [[quaternary structure]] formed by two identical monomers or protein chains. In human, three human HDC (hHDC) homodimers can be joined together to form a trimer [[asymmetric unit]] <ref name=jbc/> <ref name=xray>PMID: 22684068</ref>. Thus, one can use the nomenclature “trimer of dimer” to suggest the complex might dissociate into smaller subunits before dissociating into monomers. The asymmetrical unit can be seen in Figure 1. Specifically, <scene name='56/564049/Cys180/1'>Cys-180</scene> and Cys-418 are primary responsible for the oligomerization process of HDC <ref name=xray/>.		Histidine Decarboxylase is considered to be a homo-dimer when one observe its [[biological assembly]] <ref name=mast/>. A homodimer is a [[quaternary structure]] formed by two identical monomers or protein chains. In human, three human HDC (hHDC) homodimers can be joined together to form a trimer [[asymmetric unit]] <ref name=jbc/> <ref name=xray>PMID: 22684068</ref>. Thus, one can use the nomenclature “trimer of dimer” to suggest the complex might dissociate into smaller subunits before dissociating into monomers. The asymmetrical unit can be seen in Figure 1. Specifically, <scene name='56/564049/Cys180/1'>Cys-180</scene> and <scene name='56/564049/Cys418/1'>Cys-418</scene> are primary responsible for the oligomerization process of HDC <ref name=xray/>.