Sandbox Reserved 773: Difference between revisions

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== Sequence and Structure ==

Histidine Decarboxylase is considered to be a homo-dimer when one observe its [[biological assembly]] <ref name=mast/>. A homodimer is a [[quaternary structure]] formed by two identical monomers or protein chains. In human, three human HDC (hHDC) homodimers can be joined together to form a trimer [[asymmetric unit]] <ref name=jbc/> <ref name=xray>PMID: 22684068</ref>. Thus, one can use the nomenclature “trimer of dimer” to suggest the complex might dissociate into smaller subunits before dissociating into monomers~~. The asymmetrical unit can be seen in Figure 1~~. Specifically, <scene name='56/564049/Cys180/1'>Cys-180</scene> and <scene name='56/564049/Cys418/1'>Cys-418</scene> are ~~primary responsible~~ for the oligomerization process of HDC <ref name=xray/>.

Histidine Decarboxylase is considered to be a homo-dimer when one observe its [[biological assembly]] <ref name=mast/>. A homodimer is a [[quaternary structure]] formed by two identical monomers or protein chains. In human, three human HDC (hHDC) homodimers can be joined together to form a trimer in the [[asymmetric unit]] which can be seen in the 3D <scene name='56/564049/Front/1'>model</scene> <ref name=jbc/> <ref name=xray>PMID: 22684068</ref>. Thus, one can use the nomenclature “trimer of dimer” to suggest the complex might dissociate into smaller subunits before dissociating into monomers. Specifically, <scene name='56/564049/Cys180/1'>Cys-180</scene> and <scene name='56/564049/Cys418/1'>Cys-418</scene> are found to account for the oligomerization process of the HDC complex<ref name=xray/>.

Sandbox Reserved 773: Difference between revisions

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Revision as of 12:30, 2 December 2013 view source Wesley Yang (talk \| contribs) 185 edits →Sequence and Structure ← Older edit		Revision as of 12:36, 2 December 2013 view source Wesley Yang (talk \| contribs) 185 edits →Sequence and Structure Newer edit →
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	== Sequence and Structure ==		== Sequence and Structure ==

	Histidine Decarboxylase is considered to be a homo-dimer when one observe its [[biological assembly]] <ref name=mast/>. A homodimer is a [[quaternary structure]] formed by two identical monomers or protein chains. In human, three human HDC (hHDC) homodimers can be joined together to form a trimer [[asymmetric unit]] <ref name=jbc/> <ref name=xray>PMID: 22684068</ref>. Thus, one can use the nomenclature “trimer of dimer” to suggest the complex might dissociate into smaller subunits before dissociating into monomers~~. The asymmetrical unit can be seen in Figure 1~~. Specifically, <scene name='56/564049/Cys180/1'>Cys-180</scene> and <scene name='56/564049/Cys418/1'>Cys-418</scene> are ~~primary responsible~~ for the oligomerization process of HDC <ref name=xray/>.		Histidine Decarboxylase is considered to be a homo-dimer when one observe its [[biological assembly]] <ref name=mast/>. A homodimer is a [[quaternary structure]] formed by two identical monomers or protein chains. In human, three human HDC (hHDC) homodimers can be joined together to form a trimer in the [[asymmetric unit]] which can be seen in the 3D <scene name='56/564049/Front/1'>model</scene> <ref name=jbc/> <ref name=xray>PMID: 22684068</ref>. Thus, one can use the nomenclature “trimer of dimer” to suggest the complex might dissociate into smaller subunits before dissociating into monomers. Specifically, <scene name='56/564049/Cys180/1'>Cys-180</scene> and <scene name='56/564049/Cys418/1'>Cys-418</scene> are found to account for the oligomerization process of the HDC complex<ref name=xray/>.