2qtc: Difference between revisions

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[[Image:2qtc.jpg|left|200px]]<br /><applet load="2qtc" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2qtc.jpg|left|200px]]
caption="2qtc, resolution 1.770&Aring;" />
 
'''E. coli Pyruvate dehydrogenase E1 component E401K mutant with phosphonolactylthiamin diphosphate'''<br />
{{Structure
|PDB= 2qtc |SIZE=350|CAPTION= <scene name='initialview01'>2qtc</scene>, resolution 1.770&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=TDK:3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-{(1S)-1-HYDROXY-1-[(R)-HYDROXY(METHOXY)PHOSPHORYL]ETHYL}-5-(2-{[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}ETHYL)-4-METHYL-1,3-THIAZOL-3-IUM'>TDK</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Pyruvate_dehydrogenase_(acetyl-transferring) Pyruvate dehydrogenase (acetyl-transferring)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.4.1 1.2.4.1]
|GENE= aceE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''E. coli Pyruvate dehydrogenase E1 component E401K mutant with phosphonolactylthiamin diphosphate'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2QTC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=TDK:'>TDK</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pyruvate_dehydrogenase_(acetyl-transferring) Pyruvate dehydrogenase (acetyl-transferring)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.4.1 1.2.4.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QTC OCA].  
2QTC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QTC OCA].  


==Reference==
==Reference==
A dynamic loop at the active center of the Escherichia coli pyruvate dehydrogenase complex E1 component modulates substrate utilization and chemical communication with the E2 component., Kale S, Arjunan P, Furey W, Jordan F, J Biol Chem. 2007 Sep 21;282(38):28106-16. Epub 2007 Jul 17. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17635929 17635929]
A dynamic loop at the active center of the Escherichia coli pyruvate dehydrogenase complex E1 component modulates substrate utilization and chemical communication with the E2 component., Kale S, Arjunan P, Furey W, Jordan F, J Biol Chem. 2007 Sep 21;282(38):28106-16. Epub 2007 Jul 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17635929 17635929]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Pyruvate dehydrogenase (acetyl-transferring)]]
[[Category: Pyruvate dehydrogenase (acetyl-transferring)]]
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[[Category: x-ray diffraction]]
[[Category: x-ray diffraction]]


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