Sandbox Reserved 772: Difference between revisions
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Jah Ia Yang (talk | contribs) No edit summary |
Jah Ia Yang (talk | contribs) No edit summary |
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'''Related Structures''': [http://proteopedia.org/wiki/index.php/1kae 1KAE] and [http://proteopedia.org/wiki/index.php/1kar 1KAR] | '''Related Structures''': [http://proteopedia.org/wiki/index.php/1kae 1KAE] and [http://proteopedia.org/wiki/index.php/1kar 1KAR] | ||
'''Sequence of HDH''' | |||
[[Image:403px-Histidine decarboxylase seq.png]] | |||
==Enzymatic Mechanism== | ==Enzymatic Mechanism== | ||
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The process is as follows: | The process is as follows: | ||
1. extraction of one proton and one hydride from L-histidinol | |||
2. reduced NADH leaves and replaced by NAD+ | |||
3. repeat the first step | |||
4. His-327 abstracts a proton from the hydroxyl group, and the second NAD+ molecule is reduced by a hydride | |||
5. formation of l-histidine<ref name="pnas">http://www.pnas.org.prox.lib.ncsu.edu/content/99/4/1859.full.pdf</ref> | |||
==Implications or Possible Applications== | ==Implications or Possible Applications== | ||
