Sandbox Reserved 772: Difference between revisions
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==Structure== | ==Structure== | ||
The overall structure is 48% helical (20 helices; 211 residues) and 16% beta sheet (15 strands; 73 residues).<ref name="structure">http://www.rcsb.org/pdb/explore/remediatedSequence.do?structureId=1K75&bionumber=1</ref> | The overall structure is 48% helical (20 helices; 211 residues) and 16% beta sheet (15 strands; 73 residues).<ref name="structure">http://www.rcsb.org/pdb/explore/remediatedSequence.do?structureId=1K75&bionumber=1</ref> | ||
HDH is a monomer, but it functions as a homodimer. The presence of Zn2+ cation is required per monomer. Each HDH monomer is made of four domains,two larger domains (globule) and two smaller domains (extending tail), and the intertwined dimer was thought to result from domain swapping. The two domains presents a similar incomplete Rossmann fold, which suggests an ancient event of gene duplication. Residues from both monomers form the active site. The active site (residue His-327) participates in acid-base catalysis <ref name="pnas">http://www.pnas.org.prox.lib.ncsu.edu/content/99/4/1859.full.pdf</ref> | |||
'''Related Structures''': [http://proteopedia.org/wiki/index.php/1kae 1KAE] and [http://proteopedia.org/wiki/index.php/1kar 1KAR] | '''Related Structures''': [http://proteopedia.org/wiki/index.php/1kae 1KAE] and [http://proteopedia.org/wiki/index.php/1kar 1KAR] | ||
