2qwk: Difference between revisions

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[[Image:2qwk.gif|left|200px]]<br /><applet load="2qwk" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2qwk.gif|left|200px]]
caption="2qwk, resolution 1.8&Aring;" />
 
'''THE X-RAY STRUCTURE OF A COMPLEX OF 5-N-ACETYL-5-AMINO-3-(1-ETHYLPROPOXY)-1-CYCLOHEXENE-1-CARBOXYLIC ACID (GS4071) AND WILDTYPE TERN N9 INFLUENZA VIRUS NEURAMINIDASE'''<br />
{{Structure
|PDB= 2qwk |SIZE=350|CAPTION= <scene name='initialview01'>2qwk</scene>, resolution 1.8&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=G39:5-N-ACETYL-3-(1-ETHYLPROPYL)-1-CYCLOHEXENE-1-CARBOXYLIC ACID'>G39</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18]
|GENE=
}}
 
'''THE X-RAY STRUCTURE OF A COMPLEX OF 5-N-ACETYL-5-AMINO-3-(1-ETHYLPROPOXY)-1-CYCLOHEXENE-1-CARBOXYLIC ACID (GS4071) AND WILDTYPE TERN N9 INFLUENZA VIRUS NEURAMINIDASE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2QWK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=G39:'>G39</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QWK OCA].  
2QWK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QWK OCA].  


==Reference==
==Reference==
Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase., Varghese JN, Smith PW, Sollis SL, Blick TJ, Sahasrabudhe A, McKimm-Breschkin JL, Colman PM, Structure. 1998 Jun 15;6(6):735-46. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9655825 9655825]
Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase., Varghese JN, Smith PW, Sollis SL, Blick TJ, Sahasrabudhe A, McKimm-Breschkin JL, Colman PM, Structure. 1998 Jun 15;6(6):735-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9655825 9655825]
[[Category: Exo-alpha-sialidase]]
[[Category: Exo-alpha-sialidase]]
[[Category: Influenza a virus]]
[[Category: Influenza a virus]]
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[[Category: G39]]
[[Category: G39]]
[[Category: NAG]]
[[Category: NAG]]
[[Category: dana anologues]]
[[Category: dana anologue]]
[[Category: drug resistant variant]]
[[Category: drug resistant variant]]
[[Category: glycosylated protein]]
[[Category: glycosylated protein]]
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[[Category: influenza protein]]
[[Category: influenza protein]]
[[Category: neuraminidase]]
[[Category: neuraminidase]]
[[Category: sialic acid analogues]]
[[Category: sialic acid analogue]]


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