4ifh: Difference between revisions
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{{STRUCTURE_4ifh| PDB=4ifh | SCENE= }} | |||
===Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> | |||
==About this Structure== | |||
[[4ifh]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4gse 4gse]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IFH OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Insulysin]] | |||
[[Category: Deprez, B.]] | |||
[[Category: Deprez, R.]] | |||
[[Category: Guo, Q.]] | |||
[[Category: Liang, W G.]] | |||
[[Category: Tang, W.]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Insulin degrading enzyme]] | |||
Revision as of 10:16, 18 December 2013
Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619
Function
[IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.[1] [2] [3]
About this Structure
4ifh is a 2 chain structure. This structure supersedes the now removed PDB entry 4gse. Full crystallographic information is available from OCA.
Reference
- ↑ Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci. 2000 Mar 1;20(5):1657-65. PMID:10684867
- ↑ Im H, Manolopoulou M, Malito E, Shen Y, Zhao J, Neant-Fery M, Sun CY, Meredith SC, Sisodia SS, Leissring MA, Tang WJ. Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. J Biol Chem. 2007 Aug 31;282(35):25453-63. Epub 2007 Jul 5. PMID:17613531 doi:10.1074/jbc.M701590200
- ↑ Malito E, Ralat LA, Manolopoulou M, Tsay JL, Wadlington NL, Tang WJ. Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme. Biochemistry. 2008 Nov 6. PMID:18986166 doi:10.1021/bi801192h
