4nkg: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of SspH1 LRR domain in complex PKN1 HR1b domain===

~~The entry 4nkg~~ is ~~ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/SSPH1_SALT1 SSPH1_SALT1]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host PKN1. Down-modulates production of host proinflammatory cytokines by inhibiting NF-kappa-B-dependent gene expression, probably via interaction with PKN1.<ref>PMID:10564523</ref> <ref>PMID:12819095</ref> <ref>PMID:16611232</ref> <ref>PMID:18005683</ref> [[http://www.uniprot.org/uniprot/PKN1_HUMAN PKN1_HUMAN]] PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.<ref>PMID:8557118</ref> <ref>PMID:8621664</ref> <ref>PMID:9175763</ref> <ref>PMID:11104762</ref> <ref>PMID:12514133</ref> <ref>PMID:17332740</ref> <ref>PMID:18066052</ref> <ref>PMID:20188095</ref> <ref>PMID:21754995</ref>

~~Authors~~: ~~Keszei, A.F.A., Xiaojing, T., Mccormick, C., Zeqiraj, E., Rohde, J~~.R.~~, Tyers, M~~.~~, Sicheri, F~~.

==About this Structure==

[[4nkg]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NKG OCA].

~~Description~~: ~~Crystal structure of SspH1 LRR domain in~~ complex ~~PKN1 HR1b domain~~

==Reference==

[[Category: Protein kinase C]]

[[Category: Keszei, A F.A.]]

[[Category: Mccormick, C.]]

[[Category: Rohde, J R.]]

[[Category: Sicheri, F.]]

[[Category: Tyers, M.]]

[[Category: Xiaojing, T.]]

[[Category: Zeqiraj, E.]]

[[Category: Coiled-coil]]

[[Category: E3 ligase substrate interaction]]

[[Category: Leucine-rich repeat]]

[[Category: Ligase-transferase complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4nkg|  PDB=4nkg  |  SCENE=  }}
+===Crystal structure of SspH1 LRR domain in complex PKN1 HR1b domain===
+{{ABSTRACT_PUBMED_24248594}}
-The entry 4nkg is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/SSPH1_SALT1 SSPH1_SALT1]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host PKN1. Down-modulates production of host proinflammatory cytokines by inhibiting NF-kappa-B-dependent gene expression, probably via interaction with PKN1.<ref>PMID:10564523</ref> <ref>PMID:12819095</ref> <ref>PMID:16611232</ref> <ref>PMID:18005683</ref>  [[http://www.uniprot.org/uniprot/PKN1_HUMAN PKN1_HUMAN]] PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.<ref>PMID:8557118</ref> <ref>PMID:8621664</ref> <ref>PMID:9175763</ref> <ref>PMID:11104762</ref> <ref>PMID:12514133</ref> <ref>PMID:17332740</ref> <ref>PMID:18066052</ref> <ref>PMID:20188095</ref> <ref>PMID:21754995</ref>
-Authors: Keszei, A.F.A., Xiaojing, T., Mccormick, C., Zeqiraj, E., Rohde, J.R., Tyers, M., Sicheri, F.
+==About this Structure==
+[[4nkg]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NKG OCA].
-Description: Crystal structure of SspH1 LRR domain in complex PKN1 HR1b domain
+==Reference==
+<ref group="xtra">PMID:024248594</ref><references group="xtra"/><references/>
+[[Category: Protein kinase C]]
+[[Category: Keszei, A F.A.]]
+[[Category: Mccormick, C.]]
+[[Category: Rohde, J R.]]
+[[Category: Sicheri, F.]]
+[[Category: Tyers, M.]]
+[[Category: Xiaojing, T.]]
+[[Category: Zeqiraj, E.]]
+[[Category: Coiled-coil]]
+[[Category: E3 ligase substrate interaction]]
+[[Category: Leucine-rich repeat]]
+[[Category: Ligase-transferase complex]]