2qxx: Difference between revisions

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'''Bifunctional dCTP deaminase: dUTPase from Mycobacterium tuberculosis in complex with dTTP'''<br />

2QXX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=TTP:'>TTP</scene> and <scene name='pdbligand=1PE:'>1PE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/dCTP_deaminase dCTP deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.13 3.5.4.13] Known structural/functional Sites: <scene name='pdbsite=AC1:Mg+Binding+Site+For+Residue+A+202'>AC1</scene>, <scene name='pdbsite=AC2:Mg+Binding+Site+For+Residue+B+202'>AC2</scene>, <scene name='pdbsite=AC3:Ttp+Binding+Site+For+Residue+A+201'>AC3</scene>, <scene name='pdbsite=AC4:Ttp+Binding+Site+For+Residue+B+201'>AC4</scene>, <scene name='pdbsite=AC5:1pe+Binding+Site+For+Residue+A+203'>AC5</scene>, <scene name='pdbsite=AC6:1pe+Binding+Site+For+Residue+B+203'>AC6</scene> and <scene name='pdbsite=AC7:1pe+Binding+Site+For+Residue+B+204'>AC7</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QXX OCA].  

Mechanism of dTTP inhibition of the bifunctional dCTP deaminase:dUTPase encoded by Mycobacterium tuberculosis., Helt SS, Thymark M, Harris P, Aagaard C, Dietrich J, Larsen S, Willemoes M, J Mol Biol. 2008 Feb 15;376(2):554-69. Epub 2007 Dec 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18164314 18164314]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:43:15 2008''