4nrv: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Crystal Structure of non-edited human NEIL1===

~~The entry 4nrv is ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/NEIL1_HUMAN NEIL1_HUMAN]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches.<ref>PMID:12200441</ref> <ref>PMID:12509226</ref> <ref>PMID:11904416</ref> <ref>PMID:14522990</ref>

~~Authors~~: ~~Prakash, A~~.~~, Doublie, S~~.

==About this Structure==

[[4nrv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NRV OCA].

~~Description~~: ~~Crystal Structure of non~~-~~edited human NEIL1~~

==Reference==

[[Category: Doublie, S.]]

[[Category: Prakash, A.]]

[[Category: Dna glycosylase]]

[[Category: Helix two-turns helix motif]]

[[Category: Hydrolase]]

[[Category: Lyase]]

[[Category: Zincless finger domain]]

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-'''Unreleased structure'''
+{{STRUCTURE_4nrv|  PDB=4nrv  |  SCENE=  }}
+===Crystal Structure of non-edited human NEIL1===
-The entry 4nrv is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/NEIL1_HUMAN NEIL1_HUMAN]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches.<ref>PMID:12200441</ref> <ref>PMID:12509226</ref> <ref>PMID:11904416</ref> <ref>PMID:14522990</ref>
-Authors: Prakash, A., Doublie, S.
+==About this Structure==
+[[4nrv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NRV OCA].
-Description: Crystal Structure of non-edited human NEIL1
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Doublie, S.]]
+[[Category: Prakash, A.]]
+[[Category: Dna glycosylase]]
+[[Category: Helix two-turns helix motif]]
+[[Category: Hydrolase]]
+[[Category: Lyase]]
+[[Category: Zincless finger domain]]