Sandbox Reserved 763: Difference between revisions
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===3D Structures in Different Organisms=== | ===3D Structures in Different Organisms=== | ||
''Mycobacterium tuberculosis'' | ''Mycobacterium tuberculosis'' | ||
[[2iyt]] - MtSK (unliganded, open lid) | [[2iyt]] - MtSK (unliganded, open lid) | ||
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[[2iyz]] - MtSK + ADP + shikimate-3-phosphate | [[2iyz]] - MtSK + ADP + shikimate-3-phosphate | ||
[[4bqs]] - MtSK + ADP + shikimic acid | [[4bqs]] - MtSK + ADP + shikimic acid | ||
[[2g1j]] - MtSK + AMPPCP (ATP analogue)+ shikimic acid | |||
[[1zyu]] - MtSK + AMPPCP + shikimate | [[1zyu]] - MtSK + AMPPCP + shikimate | ||
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The liganded state of SK includes binary complexes with SO4 or MgADP ([[1l4y]]) and ternary complexes with shikimate as the first ligand and SO4 ([[2g1k]]), ADP ([[1u8a]]), MgADP, or AMPPCP (an ATP analogue) ([[1zyu]]) as the second ligand.<ref name="miscinfo" /> | The liganded state of SK includes binary complexes with SO4 or MgADP ([[1l4y]]) and ternary complexes with shikimate as the first ligand and SO4 ([[2g1k]]), ADP ([[1u8a]]), MgADP, or AMPPCP (an ATP analogue) ([[1zyu]]) as the second ligand.<ref name="miscinfo" /> | ||
SO4 | |||
MgADP | |||
ADP | |||
AMPPCP | |||
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Ligands associated with shikimate kinase include ADP, CL, shikimate (SKM), and TRS. | Ligands associated with shikimate kinase include ADP, CL, shikimate (SKM), and TRS. | ||
Adenosine-5'-sisphosphate (ADP | Adenosine-5'-sisphosphate (<scene name='56/564039/Adpligand/1'>ADP</scene> | ||
Chloride ion (<scene name='56/564039/Clligand/1'>CL</scene>) | Chloride ion (<scene name='56/564039/Clligand/1'>CL</scene>) | ||
(3R,4S,5R)-3,4,5-trihydroxycyclohex-1-ene-1-caroxylic acid (SKM) | (3R,4S,5R)-3,4,5-trihydroxycyclohex-1-ene-1-caroxylic acid (<scene name='56/564039/Skmligand/1'>SKM</scene>) | ||
2-amino-2-hydroxymethyl-propane-1,3-diol (TRS) | 2-amino-2-hydroxymethyl-propane-1,3-diol (TRS) | ||
