Sandbox Reserved 766: Difference between revisions
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'''Asparagine Synthetase''' is a homodimer comprised of two identical domains ligated together. ASPS consists of a Glutamine Amidotransferase type-2 (residues 2-191) and and Asparagine Synthetase complex (residues 213-536). There are two specific domains that contain the substrate binding sites. The N-terminal domain which contains two layers of anti-parallel beta sheets comprised of six layers each,(site PDB)this is where the Glutamine binds. A C-terminal domain also exists, it is comprised of five parallel beta sheets with alpha helices on either side of it, (site PDB) this is where the Mg2+, ATP and Aspartic Acid bind. The two active sites contained within the terminal domains are linked together by a tunnel of hydrophobic and polar surface amino acid residues. | '''Asparagine Synthetase''' is a homodimer comprised of two identical domains ligated together. ASPS consists of a Glutamine Amidotransferase type-2 (residues 2-191) and and Asparagine Synthetase complex (residues 213-536). There are two specific domains that contain the substrate binding sites. The N-terminal domain which contains two layers of anti-parallel beta sheets comprised of six layers each,(site PDB)this is where the Glutamine binds. A C-terminal domain also exists, it is comprised of five parallel beta sheets with alpha helices on either side of it, (site PDB) this is where the Mg2+, ATP and Aspartic Acid bind. The two active sites contained within the terminal domains are linked together by a tunnel of hydrophobic and polar surface amino acid residues. | ||
===Amino Acid Composition=== | ===Amino Acid Composition=== | ||
[[Image:Screen Shot 2013-12-04 at 7.18.44 PM.png |480px|| | |||
The Entire amino acid sequence for this enzyme complex can be found below. | |||
[[Image:Screen Shot 2013-12-04 at 7.18.44 PM.png |480px||left|]] | |||
== Function == | == Function == | ||
