Sandbox Reserved 766: Difference between revisions
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==Future Research and Prospective Applications For Asparagine Synthetase== | ==Future Research and Prospective Applications For Asparagine Synthetase== | ||
===Leukemia Treatment=== | ===Leukemia Treatment=== | ||
L-Asparaginase is a naturally occurring enzyme in bacteria that breaks down Asparagine. This easy breakdown of Asparagine into Aspartic Acid and Ammonia by L-Asparagine is able to suppress tumor cell growth cause by lymphoblastic leukemia cells by depleting the Asparagine stores creating a shortage in the plasma of the cell that cannot be compensated for potentially leading to apoptosis of the cell. (site DRL)Sometimes L-Asparaginase activity does not work to suppress the tumor cells. A recent study has been conducted to see if what could potentially cause some cells to be susceptible to treatment and others not be from within the same system. Leukemia infected cell lines were analyzed to see which ones were L-Asparaginase treatment immune and then those cell lines analyzed for protein expression and composition. It was found that in the cell lines that were immune to treatment there was an over expression of ASNS and therefore, an over expression of Asparagine to be used for maintenance and growth of the cells plasma. These findings are being evaluated and a potential new approach to treat lymphoblastic leukemia by using techniques such as RNAi silencing to suppress ASNS activity and allow L-Asparaginase to induce apoptosis in the cancerous cells. | |||
===Ovarian Cancer Predictive Bio-Marker=== | ===Ovarian Cancer Predictive Bio-Marker=== | ||
Recent studies have been trying to find a potential link between the amount of ASNS activity in certain cell cultures as a precursor for L-Asparaginase activity. L-Asparaginase is an enzyme that degrades Asparagine and has been used since the 1970's in basic cancer treatment plans for acute lympohoblastic leukemia (site MCT). The body will naturally secrete L-Asparaginase as a response to a potential forming tumor or potential cancer cell aggregation. These studies are finding a correlation between the amount of ASNS being expressed prior to the expression of L-Asparaginase synthetase, since L-Asparaginase has only been shown to help combat lympohoblastic leukemia this would not be a direct treatment but rather an indicator that something is happening that requires attention and hopefully allow doctors to screen for ASNS activity and catch ovarian cancer in it's earlier stages when it is more treatable and easier to remove from the body. | Recent studies have been trying to find a potential link between the amount of ASNS activity in certain cell cultures as a precursor for L-Asparaginase activity. L-Asparaginase is an enzyme that degrades Asparagine and has been used since the 1970's in basic cancer treatment plans for acute lympohoblastic leukemia (site MCT). The body will naturally secrete L-Asparaginase as a response to a potential forming tumor or potential cancer cell aggregation. These studies are finding a correlation between the amount of ASNS being expressed prior to the expression of L-Asparaginase synthetase, since L-Asparaginase has only been shown to help combat lympohoblastic leukemia this would not be a direct treatment but rather an indicator that something is happening that requires attention and hopefully allow doctors to screen for ASNS activity and catch ovarian cancer in it's earlier stages when it is more treatable and easier to remove from the body. | ||
