Sandbox Reserved 765: Difference between revisions
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If we examine the image above we can see that FMN gets reduced and the phosphate group that is on carbon number 3 within the cyclic structure is removed and replaced by a double bond between carbon 2 and 3. | If we examine the image above we can see that FMN gets reduced and the phosphate group that is on carbon number 3 within the cyclic structure is removed and replaced by a double bond between carbon 2 and 3. | ||
[[Image:HIS 17 and HIS 106.png|260px|left|thumb|This is a representation of the two essential amino acids sites, HIS 17 and HIS 106.]] | [[Image:HIS 17 and HIS 106.png|260px|left|thumb|This is a representation of the two essential amino acids sites, HIS 17 and HIS 106.]] | ||
The image to the left shows the two essential amino acid sites that are necessary for the conversion of 5-enolpyruvylshikimate-3-phosphate into chorismate <ref>PMID:14668332</ref>. It is required that the two active site be within 3Å in distance for the reaction to take place. This is why we know that HIS 106 is required for the reaction but not sure as to what role it plays exactly. | The image to the left shows the two essential amino acid sites that are necessary for the conversion of 5-enolpyruvylshikimate-3-phosphate into chorismate <ref>PMID:14668332</ref>. It is required that the two active site be within 3Å in distance for the reaction to take place. This is why we know that HIS 106 is required for the reaction but not sure as to what role it plays exactly. | ||
===Inhibition=== | |||
Chorismate synthase can be inhibited by many molecules which is effective for antimicrobial drugs because this process only takes place in microorganisms and plants. One common inhibition is through (6R)-6-Fluoro-5-enolpyruvylshikimate-3-phosphate <ref>PMID:10956653</ref>. This molecule is able to convert 5-enolpyruvylshikimate-3-phosphate into chorismate but stays attached to chorismate preventing any functionality<ref>PMID:10956653</ref>. | |||
==Implications== | ==Implications== | ||
