4m8o: Difference between revisions
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{{STRUCTURE_4m8o| PDB=4m8o | SCENE= }} | {{STRUCTURE_4m8o| PDB=4m8o | SCENE= }} | ||
===TERNARY COMPLEX OF DNA POLYMERASE EPSILON WITH AN INCOMING dATP=== | ===TERNARY COMPLEX OF DNA POLYMERASE EPSILON WITH AN INCOMING dATP=== | ||
{{ABSTRACT_PUBMED_24292646}} | |||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4m8o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M8O OCA]. | [[4m8o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M8O OCA]. | ||
==See Also== | |||
*[[DNA polymerase|DNA polymerase]] | |||
==Reference== | ==Reference== | ||
<references group="xtra"/><references/> | <ref group="xtra">PMID:024292646</ref><references group="xtra"/><references/> | ||
[[Category: Baker's yeast]] | [[Category: Baker's yeast]] | ||
[[Category: DNA-directed DNA polymerase]] | [[Category: DNA-directed DNA polymerase]] | ||
Revision as of 09:22, 19 March 2014
TERNARY COMPLEX OF DNA POLYMERASE EPSILON WITH AN INCOMING dATP
Template:ABSTRACT PUBMED 24292646
Function
[DPOE_YEAST] DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair.[1]
About this Structure
4m8o is a 3 chain structure with sequence from Baker's yeast. Full crystallographic information is available from OCA.
See Also
Reference
- Hogg M, Osterman P, Bylund GO, Ganai RA, Lundstrom EB, Sauer-Eriksson AE, Johansson E. Structural basis for processive DNA synthesis by yeast DNA polymerase varepsilon. Nat Struct Mol Biol. 2014 Jan;21(1):49-55. doi: 10.1038/nsmb.2712. Epub 2013 Dec , 1. PMID:24292646 doi:https://dx.doi.org/10.1038/nsmb.2712
- ↑ Shimizu K, Hashimoto K, Kirchner JM, Nakai W, Nishikawa H, Resnick MA, Sugino A. Fidelity of DNA polymerase epsilon holoenzyme from budding yeast Saccharomyces cerevisiae. J Biol Chem. 2002 Oct 4;277(40):37422-9. Epub 2002 Jul 17. PMID:12124389 doi:https://dx.doi.org/10.1074/jbc.M204476200
