3wi0: Difference between revisions
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{{STRUCTURE_3wi0| PDB=3wi0 | SCENE= }} | |||
===P453H/I471T mutant of PB2 middle domain from influenza virus A/Puerto Rico/8/34(H1N1)=== | |||
{{ABSTRACT_PUBMED_24312396}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PB2_I34A1 PB2_I34A1]] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity). | |||
==About this Structure== | |||
[[3wi0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WI0 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024312396</ref><references group="xtra"/><references/> | |||
[[Category: Tsuge, H.]] | |||
[[Category: Tsurumura, T.]] | |||
[[Category: Yoshida, T.]] | |||
[[Category: Cap binding]] | |||
[[Category: Influenza a virus]] | |||
[[Category: Middle domain]] | |||
[[Category: Pb2]] | |||
[[Category: Viral protein]] | |||
Revision as of 10:18, 18 December 2013
P453H/I471T mutant of PB2 middle domain from influenza virus A/Puerto Rico/8/34(H1N1)
Template:ABSTRACT PUBMED 24312396
Function
[PB2_I34A1] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity).
About this Structure
3wi0 is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Tsurumura T, Qiu H, Yoshida T, Tsumori Y, Hatakeyama D, Kuzuhara T, Tsuge H. Conformational Polymorphism of m(7)GTP in Crystal Structure of the PB2 Middle Domain from Human Influenza A Virus. PLoS One. 2013 Nov 29;8(11):e82020. doi: 10.1371/journal.pone.0082020. PMID:24312396 doi:https://dx.doi.org/10.1371/journal.pone.0082020
