3wn7: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Crystal Structure of Keap1 in Complex with the N-terminal region of the Nrf2 transcription factor===

~~The entry 3wn7 is ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE]] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref> [[http://www.uniprot.org/uniprot/NF2L2_MOUSE NF2L2_MOUSE]] Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.<ref>PMID:9887101</ref>

~~Authors~~: ~~Fukutomi, T., Takagi, K~~.~~, Mizushima, T~~.~~, Ohuchi, N~~.~~, Yamamoto, M~~.

==About this Structure==

[[3wn7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WN7 OCA].

~~Description~~: ~~Crystal Structure of Keap1 in Complex with the~~ N-~~terminal region of the Nrf2 transcription factor~~

==Reference==

[[Category: Fukutomi, T.]]

[[Category: Mizushima, T.]]

[[Category: Ohuchi, N.]]

[[Category: Takagi, K.]]

[[Category: Yamamoto, M.]]

[[Category: Beta-propeller]]

[[Category: Degron]]

[[Category: Kelch motif]]

[[Category: Transcription]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_3wn7|  PDB=3wn7  |  SCENE=  }}
+===Crystal Structure of Keap1 in Complex with the N-terminal region of the Nrf2 transcription factor===
-The entry 3wn7 is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE]] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref>  [[http://www.uniprot.org/uniprot/NF2L2_MOUSE NF2L2_MOUSE]] Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.<ref>PMID:9887101</ref>
-Authors: Fukutomi, T., Takagi, K., Mizushima, T., Ohuchi, N., Yamamoto, M.
+==About this Structure==
+[[3wn7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WN7 OCA].
-Description: Crystal Structure of Keap1 in Complex with the N-terminal region of the Nrf2 transcription factor
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Fukutomi, T.]]
+[[Category: Mizushima, T.]]
+[[Category: Ohuchi, N.]]
+[[Category: Takagi, K.]]
+[[Category: Yamamoto, M.]]
+[[Category: Beta-propeller]]
+[[Category: Degron]]
+[[Category: Kelch motif]]
+[[Category: Transcription]]