4i1t: Difference between revisions
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{{STRUCTURE_4i1t| PDB=4i1t | SCENE= }} | |||
===Crystal structure of the cap-snatching endonuclease from Pichinde virus=== | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/Q915A5_PIARV Q915A5_PIARV]] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner (By similarity).[PIRNR:PIRNR000836] | |||
==About this Structure== | |||
[[4i1t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1T OCA]. | |||
[[Category: RNA-directed RNA polymerase]] | |||
[[Category: Bussetta, C.]] | |||
[[Category: Choi, K H.]] | |||
[[Category: Arenavirus]] | |||
[[Category: Cap-snatching]] | |||
[[Category: Cap-snatching rna endonuclease]] | |||
[[Category: Endonuclease]] | |||
[[Category: L protein]] | |||
[[Category: Pichinde virus]] | |||
[[Category: Rna-dependent rna polymerase]] | |||
[[Category: Viral protein]] | |||
[[Category: Viral transcription]] | |||
