2mb7: Difference between revisions
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{{STRUCTURE_2mb7| PDB=2mb7 | SCENE= }} | {{STRUCTURE_2mb7| PDB=2mb7 | SCENE= }} | ||
===Solution structure of MBD3 methylcytosine binding domain=== | ===Solution structure of MBD3 methylcytosine binding domain=== | ||
{{ABSTRACT_PUBMED_24307175}} | |||
==Function== | ==Function== | ||
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==Reference== | ==Reference== | ||
<references group="xtra"/><references/> | <ref group="xtra">PMID:024307175</ref><references group="xtra"/><references/> | ||
[[Category: Scarsdale, J N.]] | [[Category: Scarsdale, J N.]] | ||
[[Category: Williams, D C.]] | [[Category: Williams, D C.]] | ||
Revision as of 10:52, 1 January 2014
Solution structure of MBD3 methylcytosine binding domain
Template:ABSTRACT PUBMED 24307175
Function
[MBD3_HUMAN] Acts as transcriptional repressor and plays a role in gene silencing. Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases.[1] [2] [3]
About this Structure
2mb7 is a 1 chain structure. Full experimental information is available from OCA.
Reference
- Cramer JM, Scarsdale JN, Walavalkar NM, Buchwald WA, Ginder GD, Williams DC Jr. Probing the Dynamic Distribution of Bound States for Methyl-cytosine Binding Domains on DNA. J Biol Chem. 2013 Dec 4. PMID:24307175 doi:https://dx.doi.org/10.1074/jbc.M113.512236
- ↑ Hendrich B, Bird A. Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol Cell Biol. 1998 Nov;18(11):6538-47. PMID:9774669
- ↑ Tatematsu KI, Yamazaki T, Ishikawa F. MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase. Genes Cells. 2000 Aug;5(8):677-88. PMID:10947852
- ↑ Saito M, Ishikawa F. The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. J Biol Chem. 2002 Sep 20;277(38):35434-9. Epub 2002 Jul 17. PMID:12124384 doi:https://dx.doi.org/10.1074/jbc.M203455200
