2rj7: Difference between revisions

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[[Image:2rj7.jpg|left|200px]]<br /><applet load="2rj7" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2rj7.jpg|left|200px]]
caption="2rj7, resolution 1.700&Aring;" />
 
'''B-specific alpha-1,3-galactosyltransferase G176R S235G mutant (AABB) + UDPGal + Deoxy-acceptor'''<br />
{{Structure
|PDB= 2rj7 |SIZE=350|CAPTION= <scene name='initialview01'>2rj7</scene>, resolution 1.700&Aring;
|SITE= <scene name='pdbsite=AC1:Gdu+Binding+Site+For+Residue+A+475'>AC1</scene>, <scene name='pdbsite=AC2:Mn+Binding+Site+For+Residue+A+453'>AC2</scene> and <scene name='pdbsite=AC3:Da8+Binding+Site+For+Residue+A+452'>AC3</scene>
|LIGAND= <scene name='pdbligand=GDU:GALACTOSE-URIDINE-5'-DIPHOSPHATE'>GDU</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene> and <scene name='pdbligand=DA8:'>DA8</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Fucosylgalactoside_3-alpha-galactosyltransferase Fucosylgalactoside 3-alpha-galactosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.37 2.4.1.37]
|GENE= ABO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''B-specific alpha-1,3-galactosyltransferase G176R S235G mutant (AABB) + UDPGal + Deoxy-acceptor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2RJ7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=GDU:'>GDU</scene>, <scene name='pdbligand=MN:'>MN</scene> and <scene name='pdbligand=DA8:'>DA8</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Fucosylgalactoside_3-alpha-galactosyltransferase Fucosylgalactoside 3-alpha-galactosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.37 2.4.1.37] Known structural/functional Sites: <scene name='pdbsite=AC1:Gdu+Binding+Site+For+Residue+A+475'>AC1</scene>, <scene name='pdbsite=AC2:Mn+Binding+Site+For+Residue+A+453'>AC2</scene> and <scene name='pdbsite=AC3:Da8+Binding+Site+For+Residue+A+452'>AC3</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJ7 OCA].  
2RJ7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJ7 OCA].  


==Reference==
==Reference==
ABO(H) blood group A and B glycosyltransferases recognize substrate via specific conformational changes., Alfaro JA, Zheng RB, Persson M, Letts JA, Polakowski R, Bai Y, Borisova SN, Seto NO, Lowary TL, Palcic MM, Evans SV, J Biol Chem. 2008 Jan 11;. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18192272 18192272]
ABO(H) blood group A and B glycosyltransferases recognize substrate via specific conformational changes., Alfaro JA, Zheng RB, Persson M, Letts JA, Polakowski R, Bai Y, Borisova SN, Seto NO, Lowary TL, Palcic MM, Evans SV, J Biol Chem. 2008 Jan 11;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18192272 18192272]
[[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]]
[[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: glycosyltransferase]]
[[Category: glycosyltransferase]]
[[Category: golgi apparatus]]
[[Category: golgi apparatus]]
[[Category: gtb abo rossman fold aabb closed conformation ]]
[[Category: gtb abo rossman fold aabb closed conformation]]
[[Category: manganese]]
[[Category: manganese]]
[[Category: membrane]]
[[Category: membrane]]
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[[Category: transmembrane]]
[[Category: transmembrane]]


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