4hi8: Difference between revisions

Line 1:

~~{{STRUCTURE_4hi8| PDB=4hi8 | SCENE= }}~~

==Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800==

===Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800===

== Structural highlights ==

==~~Function~~==

<table><tr><td colspan='2'>[[4hi8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HI8 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HI8 FirstGlance].

[[http://~~www~~.~~uniprot~~.org/~~uniprot~~/~~ILK_HUMAN ILK_HUMAN~~]] ~~Receptor-proximal protein kinase regulating integrin-mediated signal transduction~~. ~~May act as~~ a ~~mediator of inside~~-~~out integrin signaling~~. ~~Focal adhesion protein part of the complex~~ ILK-PINCH. ~~This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway~~. ~~Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells~~. ~~Phosphorylates beta~~-~~1 and beta~~-~~3 integrin subunit on~~ serine ~~and~~ threonine ~~residues~~, ~~but also AKT1 and GSK3B. [~~[http://www.~~uniprot~~.~~org~~/~~uniprot~~/LIMS1_HUMAN LIMS1_HUMAN]] Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. ~~Involved in the regulation of cell survival, cell proliferation and cell differentiation~~.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[3f6q|3f6q]], [[4hi9|4hi9]]</td></tr>

==~~About this Structure~~==

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">ILK, ILK1, ILK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), LIMS1, PINCH, PINCH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

[[4hi8]~~] is a 2 chain structure. Full crystallographic information is available from~~ [http://oca.weizmann.ac.il/oca-bin/~~ocashort~~?id=~~4HI8~~ OCA].

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hi8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hi8 RCSB], [http://www.ebi.ac.uk/pdbsum/4hi8 PDBsum]</td></tr>

</table>

__TOC__

</StructureSection>

[[Category: Human]]

[[Category: Non-specific serine/threonine protein kinase]]

[[Category: Boggon, T J.]]

[[Category: Boggon, T J]]

[[Category: Calderwood, D A.]]

[[Category: Calderwood, D A]]

[[Category: Chiswell, B P.]]

[[Category: Chiswell, B P]]

[[Category: Jakoncic, J.]]

[[Category: Jakoncic, J]]

[[Category: Stiegler, A L.]]

[[Category: Stiegler, A L]]

[[Category: Stojanoff, V.]]

[[Category: Stojanoff, V]]

[[Category: Ankyrin repeat lim domain]]

[[Category: Focal adhesion]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-{{STRUCTURE_4hi8|  PDB=4hi8  |  SCENE=  }}
+==Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800==
-===Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800===
+<StructureSection load='4hi8' size='340' side='right' caption='[[4hi8]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
+== Structural highlights ==
-==Function==
+<table><tr><td colspan='2'>[[4hi8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HI8 FirstGlance]. <br>
-[[http://www.uniprot.org/uniprot/ILK_HUMAN ILK_HUMAN]] Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. [[http://www.uniprot.org/uniprot/LIMS1_HUMAN LIMS1_HUMAN]] Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3f6q|3f6q]], [[4hi9|4hi9]]</td></tr>
-==About this Structure==
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ILK, ILK1, ILK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), LIMS1, PINCH, PINCH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-[[4hi8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HI8 OCA].
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hi8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hi8 RCSB], [http://www.ebi.ac.uk/pdbsum/4hi8 PDBsum]</span></td></tr>
+</table>
+__TOC__
+</StructureSection>
+[[Category: Human]]
 [[Category: Non-specific serine/threonine protein kinase]]
-[[Category: Boggon, T J.]]
+[[Category: Boggon, T J]]
-[[Category: Calderwood, D A.]]
+[[Category: Calderwood, D A]]
-[[Category: Chiswell, B P.]]
+[[Category: Chiswell, B P]]
-[[Category: Jakoncic, J.]]
+[[Category: Jakoncic, J]]
-[[Category: Stiegler, A L.]]
+[[Category: Stiegler, A L]]
-[[Category: Stojanoff, V.]]
+[[Category: Stojanoff, V]]
 [[Category: Ankyrin repeat lim domain]]
 [[Category: Focal adhesion]]