4nie: Difference between revisions

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~~{{STRUCTURE_4nie| PDB=4nie | SCENE= }}~~

==Crystal structure of the orphan nuclear receptor ROR(gamma)t ligand-binding domain in complex with small molecule ligand==

===Crystal structure of the orphan nuclear receptor ROR(gamma)t ligand-binding domain in complex with small molecule ligand===

== Structural highlights ==

==~~Function~~==

<table><tr><td colspan='2'>[[4nie]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NIE OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NIE FirstGlance].

[[http://~~www~~.~~uniprot~~.org/~~uniprot~~/~~RORG_HUMAN RORG_HUMAN~~]] ~~Possible nuclear receptor for hydroxycholesterols,~~ the ~~binding of which strongly promotes coactivators recruitment~~. ~~Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes~~. ~~Involved in lineage specification of uncommitted CD4(+) T~~-~~helper cells into Th17 cells~~. ~~Regulate the expression of several components of the circadian clock~~.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=DMX:3-[BENZYL(DIMETHYL)AMMONIO]PROPANE-1-SULFONATE'>DMX</scene>, <scene name='pdbligand=NBH:N-(4-{[BENZYL(PROPYL)AMINO]METHYL}PHENYL)-2-[4-(ETHYLSULFONYL)PHENYL]ACETAMIDE'>NBH</scene></td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">NR1F3, RORC, RORG, RZRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

==~~About this Structure~~==

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nie OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nie RCSB], [http://www.ebi.ac.uk/pdbsum/4nie PDBsum]</td></tr>

[[~~4nie~~]] ~~is a 4 chain structure~~. ~~Full crystallographic information is available from~~ [http://oca.weizmann.ac.il/oca-bin/~~ocashort~~?id=~~4NIE~~ OCA].

</table>

[[Category: Ma, Y L.]]

__TOC__

[[Category: Yang, L Q.]]

</StructureSection>

[[Category: Human]]

[[Category: Ma, Y L]]

[[Category: Yang, L Q]]

[[Category: Ligand binding domain]]

[[Category: Nuclear receptor]]

[[Category: Transcription-agonist complex]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_4nie|  PDB=4nie  |  SCENE=  }}
+==Crystal structure of the orphan nuclear receptor ROR(gamma)t ligand-binding domain in complex with small molecule ligand==
-===Crystal structure of the orphan nuclear receptor ROR(gamma)t ligand-binding domain in complex with small molecule ligand===
+<StructureSection load='4nie' size='340' side='right' caption='[[4nie]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
+== Structural highlights ==
-==Function==
+<table><tr><td colspan='2'>[[4nie]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NIE FirstGlance]. <br>
-[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMX:3-[BENZYL(DIMETHYL)AMMONIO]PROPANE-1-SULFONATE'>DMX</scene>, <scene name='pdbligand=NBH:N-(4-{[BENZYL(PROPYL)AMINO]METHYL}PHENYL)-2-[4-(ETHYLSULFONYL)PHENYL]ACETAMIDE'>NBH</scene></td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR1F3, RORC, RORG, RZRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nie OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nie RCSB], [http://www.ebi.ac.uk/pdbsum/4nie PDBsum]</span></td></tr>
-[[4nie]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NIE OCA].
+</table>
-[[Category: Ma, Y L.]]
+__TOC__
-[[Category: Yang, L Q.]]
+</StructureSection>
+[[Category: Human]]
+[[Category: Ma, Y L]]
+[[Category: Yang, L Q]]
 [[Category: Ligand binding domain]]
 [[Category: Nuclear receptor]]
 [[Category: Transcription-agonist complex]]