4na0: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4na0|  PDB=4na0  |  SCENE=  }}
===Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain with ADPRibose===


The entry 4na0 is ON HOLD  until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/PARG_MOUSE PARG_MOUSE]] Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (By similarity).


Authors: Wang, Z., Cheng, Z., Xu, W.
==About this Structure==
 
[[4na0]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NA0 OCA].
Description: Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain with ADPRibose
[[Category: Cheng, Z.]]
[[Category: Wang, Z.]]
[[Category: Xu, W.]]
[[Category: Hydrolase]]
Retrieved from "https://proteopedia.org/4na0"