4ncj: Difference between revisions
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{{STRUCTURE_4ncj| PDB=4ncj | SCENE= }} | |||
===Crystal Structure of Pyrococcus furiosis Rad50 R805E mutation with ADP Beryllium Flouride=== | |||
{{ABSTRACT_PUBMED_24493214}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/RAD50_PYRFU RAD50_PYRFU]] Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site.[HAMAP-Rule:MF_00449] | |||
==About this Structure== | |||
[[4ncj]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NCJ OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024493214</ref><references group="xtra"/><references/> | |||
[[Category: Arvai, A S.]] | |||
[[Category: Classen, S.]] | |||
[[Category: Williams, G J.]] | |||
[[Category: Williams, R S.]] | |||
[[Category: Adenosine triphosphatase]] | |||
[[Category: Dna binding protein]] | |||
[[Category: Dna repair]] | |||
[[Category: Fungal protein]] | |||
Revision as of 07:10, 2 April 2014
Crystal Structure of Pyrococcus furiosis Rad50 R805E mutation with ADP Beryllium Flouride
Template:ABSTRACT PUBMED 24493214
Function
[RAD50_PYRFU] Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site.[HAMAP-Rule:MF_00449]
About this Structure
4ncj is a 4 chain structure. Full crystallographic information is available from OCA.
Reference
- Deshpande RA, Williams GJ, Limbo O, Williams RS, Kuhnlein J, Lee JH, Classen S, Guenther G, Russell P, Tainer JA, Paull TT. ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. EMBO J. 2014 Mar 3;33(5):482-500. doi: 10.1002/embj.201386100. Epub 2014 Feb 3. PMID:24493214 doi:https://dx.doi.org/10.1002/embj.201386100
