4nyw: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Crystal Structure of the Bromodomain of human CREBBP in complex with a dihydroquinoxalinone ligand===

~~The~~ entry ~~4nyw~~ is ~~ON HOLD~~

==Disease==

[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[http://omim.org/entry/180849 180849]]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref> <ref>PMID:12114483</ref> <ref>PMID:12566391</ref> <ref>PMID:15706485</ref>

~~Authors~~: ~~Filippakopoulos, P~~.~~, Picaud, S~~., ~~Felletar, I~~., ~~Rooney, T~~.P.C.~~, Fedorov, O., Martin, S., Monteiro, O.P., Conway, S.J., Von Delft, F., Brennan, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)~~

==Function==

[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref> <ref>PMID:11154691</ref> <ref>PMID:12738767</ref> <ref>PMID:12929931</ref>

~~Description~~: ~~Crystal Structure of the~~ Bromodomain ~~of human CREBBP in complex with a dihydroquinoxalinone ligand~~

==About this Structure==

[[4nyw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NYW OCA].

==Reference==

[[Category: Arrowsmith, C H.]]

[[Category: Bountra, C.]]

[[Category: Brennan, P.]]

[[Category: Conway, S J.]]

[[Category: Delft, F Von.]]

[[Category: Edwards, A M.]]

[[Category: Fedorov, O.]]

[[Category: Felletar, I.]]

[[Category: Filippakopoulos, P.]]

[[Category: Knapp, S.]]

[[Category: Martin, S.]]

[[Category: Monteiro, O P.]]

[[Category: Picaud, S.]]

[[Category: Rooney, T P.C.]]

[[Category: SGC, Structural Genomics Consortium.]]

[[Category: Bromodomain]]

[[Category: Creb binding]]

[[Category: Crebbp]]

[[Category: Kat3a]]

[[Category: Rst]]

[[Category: Sgc]]

[[Category: Structural genomics consortium]]

[[Category: Transcription]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4nyw|  PDB=4nyw  |  SCENE=  }}
+===Crystal Structure of the Bromodomain of human CREBBP in complex with a dihydroquinoxalinone ligand===
-The entry 4nyw is ON HOLD
+==Disease==
+[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription.  Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[http://omim.org/entry/180849 180849]]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref> <ref>PMID:12114483</ref> <ref>PMID:12566391</ref> <ref>PMID:15706485</ref>
-Authors: Filippakopoulos, P., Picaud, S., Felletar, I., Rooney, T.P.C., Fedorov, O., Martin, S., Monteiro, O.P., Conway, S.J., Von Delft, F., Brennan, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
+==Function==
+[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref> <ref>PMID:11154691</ref> <ref>PMID:12738767</ref> <ref>PMID:12929931</ref>
-Description: Crystal Structure of the Bromodomain of human CREBBP in complex with a dihydroquinoxalinone ligand
+==About this Structure==
+[[4nyw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NYW OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Arrowsmith, C H.]]
+[[Category: Bountra, C.]]
+[[Category: Brennan, P.]]
+[[Category: Conway, S J.]]
+[[Category: Delft, F Von.]]
+[[Category: Edwards, A M.]]
+[[Category: Fedorov, O.]]
+[[Category: Felletar, I.]]
+[[Category: Filippakopoulos, P.]]
+[[Category: Knapp, S.]]
+[[Category: Martin, S.]]
+[[Category: Monteiro, O P.]]
+[[Category: Picaud, S.]]
+[[Category: Rooney, T P.C.]]
+[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Bromodomain]]
+[[Category: Creb binding]]
+[[Category: Crebbp]]
+[[Category: Kat3a]]
+[[Category: Rst]]
+[[Category: Rst]]
+[[Category: Sgc]]
+[[Category: Structural genomics consortium]]
+[[Category: Transcription]]