2toh: Difference between revisions

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[[Image:2toh.gif|left|200px]]<br /><applet load="2toh" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2toh.gif|left|200px]]
caption="2toh, resolution 2.30&Aring;" />
 
'''TYROSINE HYDROXYLASE CATALYTIC AND TETRAMERIZATION DOMAINS FROM RAT'''<br />
{{Structure
|PDB= 2toh |SIZE=350|CAPTION= <scene name='initialview01'>2toh</scene>, resolution 2.30&Aring;
|SITE= <scene name='pdbsite=FE:Fe+Binding+Site'>FE</scene> and <scene name='pdbsite=MTY:Pterin+Binding+Site+And+Self-Hydroxylated+Residue'>MTY</scene>
|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=HBI:7,8-DIHYDROBIOPTERIN'>HBI</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Tyrosine_3-monooxygenase Tyrosine 3-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.2 1.14.16.2]
|GENE=
}}
 
'''TYROSINE HYDROXYLASE CATALYTIC AND TETRAMERIZATION DOMAINS FROM RAT'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2TOH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=FE:'>FE</scene>, <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=HBI:'>HBI</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 2TOH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb61_1.html Phenylalanine Hydroxylase]]. Active as [http://en.wikipedia.org/wiki/Tyrosine_3-monooxygenase Tyrosine 3-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.2 1.14.16.2] Known structural/functional Sites: <scene name='pdbsite=FE:Fe+Binding+Site'>FE</scene> and <scene name='pdbsite=MTY:Pterin+Binding+Site+And+Self-Hydroxylated+Residue'>MTY</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TOH OCA].  
2TOH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. The following page contains interesting information on the relation of 2TOH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb61_1.html Phenylalanine Hydroxylase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TOH OCA].  


==Reference==
==Reference==
Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 A resolution: self-hydroxylation of Phe300 and the pterin-binding site., Goodwill KE, Sabatier C, Stevens RC, Biochemistry. 1998 Sep 29;37(39):13437-45. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9753429 9753429]
Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 A resolution: self-hydroxylation of Phe300 and the pterin-binding site., Goodwill KE, Sabatier C, Stevens RC, Biochemistry. 1998 Sep 29;37(39):13437-45. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9753429 9753429]
[[Category: Phenylalanine Hydroxylase]]
[[Category: Phenylalanine Hydroxylase]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: pterin co-substrate]]
[[Category: pterin co-substrate]]


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