2tsr: Difference between revisions

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[[Image:2tsr.jpg|left|200px]]<br /><applet load="2tsr" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2tsr.jpg|left|200px]]
caption="2tsr, resolution 2.60&Aring;" />
 
'''THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX'''<br />
{{Structure
|PDB= 2tsr |SIZE=350|CAPTION= <scene name='initialview01'>2tsr</scene>, resolution 2.60&Aring;
|SITE= <scene name='pdbsite=NUL:Catalytic+Residue,+Equivalent+To+C146+In+E.Coli+Thymidyl+...'>NUL</scene>
|LIGAND= <scene name='pdbligand=UMP:2'-DEOXYURIDINE+5'-MONOPHOSPHATE'>UMP</scene> and <scene name='pdbligand=D16:TOMUDEX'>D16</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]
|GENE=
}}
 
'''THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2TSR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=UMP:'>UMP</scene> and <scene name='pdbligand=D16:'>D16</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] Known structural/functional Site: <scene name='pdbsite=NUL:Catalytic+Residue,+Equivalent+To+C146+In+E.Coli+Thymidyl+...'>NUL</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TSR OCA].  
2TSR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TSR OCA].  


==Reference==
==Reference==
Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug., Sotelo-Mundo RR, Ciesla J, Dzik JM, Rode W, Maley F, Maley GF, Hardy LW, Montfort WR, Biochemistry. 1999 Jan 19;38(3):1087-94. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9894005 9894005]
Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug., Sotelo-Mundo RR, Ciesla J, Dzik JM, Rode W, Maley F, Maley GF, Hardy LW, Montfort WR, Biochemistry. 1999 Jan 19;38(3):1087-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9894005 9894005]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: tomudex]]
[[Category: tomudex]]


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