2tsy: Difference between revisions

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[[Image:2tsy.jpg|left|200px]]<br /><applet load="2tsy" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2tsy.jpg|left|200px]]
caption="2tsy, resolution 2.5&Aring;" />
 
'''CRYSTAL STRUCTURES OF MUTANT (BETAK87T) TRYPTOPHAN SYNTHASE ALPHA2 BETA2 COMPLEX WITH LIGANDS BOUND TO THE ACTIVE SITES OF THE ALPHA AND BETA SUBUNITS REVEAL LIGAND-INDUCED CONFORMATIONAL CHANGES'''<br />
{{Structure
|PDB= 2tsy |SIZE=350|CAPTION= <scene name='initialview01'>2tsy</scene>, resolution 2.5&Aring;
|SITE= <scene name='pdbsite=S1:Product+Analog+Bound+To+The+Alpha+Active+Site'>S1</scene> and <scene name='pdbsite=S2:Reaction+Intermediate+Bound+To+The+Beta+Active+Site'>S2</scene>
|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=G3P:SN-GLYCEROL-3-PHOSPHATE'>G3P</scene> and <scene name='pdbligand=PLS:[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE'>PLS</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20]
|GENE= TRPA/TRPB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=602 Salmonella typhimurium])
}}
 
'''CRYSTAL STRUCTURES OF MUTANT (BETAK87T) TRYPTOPHAN SYNTHASE ALPHA2 BETA2 COMPLEX WITH LIGANDS BOUND TO THE ACTIVE SITES OF THE ALPHA AND BETA SUBUNITS REVEAL LIGAND-INDUCED CONFORMATIONAL CHANGES'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2TSY is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium] with <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=G3P:'>G3P</scene> and <scene name='pdbligand=PLS:'>PLS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] Known structural/functional Sites: <scene name='pdbsite=S1:Product+Analog+Bound+To+The+Alpha+Active+Site'>S1</scene> and <scene name='pdbsite=S2:Reaction+Intermediate+Bound+To+The+Beta+Active+Site'>S2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TSY OCA].  
2TSY is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TSY OCA].  


==Reference==
==Reference==
Crystal structures of a mutant (betaK87T) tryptophan synthase alpha2beta2 complex with ligands bound to the active sites of the alpha- and beta-subunits reveal ligand-induced conformational changes., Rhee S, Parris KD, Hyde CC, Ahmed SA, Miles EW, Davies DR, Biochemistry. 1997 Jun 24;36(25):7664-80. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9201907 9201907]
Crystal structures of a mutant (betaK87T) tryptophan synthase alpha2beta2 complex with ligands bound to the active sites of the alpha- and beta-subunits reveal ligand-induced conformational changes., Rhee S, Parris KD, Hyde CC, Ahmed SA, Miles EW, Davies DR, Biochemistry. 1997 Jun 24;36(25):7664-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9201907 9201907]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Salmonella typhimurium]]
[[Category: Salmonella typhimurium]]
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[[Category: tryptophan biosynthesis]]
[[Category: tryptophan biosynthesis]]


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