4kzi: Difference between revisions

Line 1:

~~{{STRUCTURE_4kzi| PDB=4kzi | SCENE= }}~~

==Crystal Structure of TR3 LBD in complex with DPDO==

===Crystal Structure of TR3 LBD in complex with DPDO===

== Structural highlights ==

==~~Function~~==

<table><tr><td colspan='2'>[[4kzi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZI OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KZI FirstGlance].

[[http://~~www~~.~~uniprot~~.org/~~uniprot~~/~~NR4A1_HUMAN NR4A1_HUMAN~~]] ~~Orphan nuclear receptor~~. ~~May act concomitantly with NURR1 in regulating~~ the ~~expression of delayed~~-~~early genes during liver regeneration~~. ~~Binds the NGFI~~-~~B response element~~ (~~NBRE~~) 5'-~~AAAAGGTCA~~-3' (~~By similarity)~~. ~~May inhibit NF-kappa-B transactivation of IL2~~.<~~ref~~>~~PMID:15466594~~</~~ref~~>

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZJ0:1-(3,5-DIMETHOXYPHENYL)DECAN-1-ONE'>ZJ0</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4kzj|4kzj]], [[4kzm|4kzm]], [[4jgv|4jgv]]</td></tr>

==~~About this Structure~~==

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">GFRP1, HMR, NAK1, NR4A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

[[4kzi]~~] is a 2 chain structure. Full crystallographic information is available from~~ [http://oca.weizmann.ac.il/oca-bin/~~ocashort~~?id=~~4KZI~~ OCA].

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kzi RCSB], [http://www.ebi.ac.uk/pdbsum/4kzi PDBsum]</td></tr>

</table>

~~==Reference=~~=

__TOC__

<~~references group="xtra"~~/><~~references~~/>

</StructureSection>

[[Category: Cai, Q.]]

[[Category: Human]]

[[Category: Chen, H.]]

[[Category: Cai, Q]]

[[Category: Li, A.]]

[[Category: Chen, H]]

[[Category: Li, F.]]

[[Category: Li, A]]

[[Category: Lin, T.]]

[[Category: Li, F]]

[[Category: Tian, X.]]

[[Category: Lin, T]]

[[Category: Wang, W.]]

[[Category: Tian, X]]

[[Category: Wang, Y.]]

[[Category: Wang, W]]

[[Category: Wu, Q.]]

[[Category: Wang, Y]]

[[Category: Xing, Y.]]

[[Category: Wu, Q]]

[[Category: Zhang, Q.]]

[[Category: Xing, Y]]

[[Category: Zhang, Q]]

[[Category: Orphan nuclear receptor]]

[[Category: Transcription]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_4kzi|  PDB=4kzi  |  SCENE=  }}
+==Crystal Structure of TR3 LBD in complex with DPDO==
-===Crystal Structure of TR3 LBD in complex with DPDO===
+<StructureSection load='4kzi' size='340' side='right' caption='[[4kzi]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
+== Structural highlights ==
-==Function==
+<table><tr><td colspan='2'>[[4kzi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KZI FirstGlance]. <br>
-[[http://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN]] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZJ0:1-(3,5-DIMETHOXYPHENYL)DECAN-1-ONE'>ZJ0</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kzj|4kzj]], [[4kzm|4kzm]], [[4jgv|4jgv]]</td></tr>
-==About this Structure==
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GFRP1, HMR, NAK1, NR4A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-[[4kzi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KZI OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kzi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kzi RCSB], [http://www.ebi.ac.uk/pdbsum/4kzi PDBsum]</span></td></tr>
+</table>
-==Reference==
+__TOC__
-<references group="xtra"/><references/>
+</StructureSection>
-[[Category: Cai, Q.]]
+[[Category: Human]]
-[[Category: Chen, H.]]
+[[Category: Cai, Q]]
-[[Category: Li, A.]]
+[[Category: Chen, H]]
-[[Category: Li, F.]]
+[[Category: Li, A]]
-[[Category: Lin, T.]]
+[[Category: Li, F]]
-[[Category: Tian, X.]]
+[[Category: Lin, T]]
-[[Category: Wang, W.]]
+[[Category: Tian, X]]
-[[Category: Wang, Y.]]
+[[Category: Wang, W]]
-[[Category: Wu, Q.]]
+[[Category: Wang, Y]]
-[[Category: Xing, Y.]]
+[[Category: Wu, Q]]
-[[Category: Zhang, Q.]]
+[[Category: Xing, Y]]
+[[Category: Zhang, Q]]
 [[Category: Orphan nuclear receptor]]
 [[Category: Transcription]]