Interleukin-1 beta: Difference between revisions

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'''THREE-DIMENSIONAL STRUCTURE OF IL-1β'''

"The molecule ~~resembles~~ a conical barrel with a shallow open face on one end and a closed face on the other. The molecule contains 12 antiparallel 13-strands, where six of these (131, 14, 15, 18, 19, and 1312) constitute an antiparallel 1 barrel. The overall structure of the molecule consists of three similar fragments (Fl, F2, F3), each containing two pairs of 1 strands. Three pairs of 1 strands (one pair from each of the fragments) form the six stranded barrel; the other three pairs cover one end of the barrel, referred to as the "closed end." The amino and carboxy termini are close to each other at the "open end" of the barrel~~. The molecule has internal pseudo threefold symmetry, with each subunit (Fl, F2, F3) having a 13L13 motif~~. There are five 1-hairpins in this molecule, two of them in the open end and three at the closed end. 24 hydrophobic side chains line the inner surface of the barrel and both the ends of the barrel have concentrations of exposed polar residues."[4]

The molecule contains 12 antiparallel β-strands. The molecule has internal pseudo threefold symmetry with the molecule represents a conical barrel with a shallow open face on one end and a closed face on the other. The amino and carboxy termini are close to each other at the "open end" of the barrel. There are five 1-hairpins in this molecule, two of them in the open end and three at the closed end. 24 hydrophobic side chains line the inner surface of the barrel and both the ends of the barrel have concentrations of exposed polar residues. More detail structure information could be found in reference[4].

<scene name='57/571319/Scene1/1'>Human Interleukin-1 beta</scene> are present in the 3D structure. In the picture we could see <scene name='57/571319/Scene1/2'>helix</scene> was colored as purple and <scene name='57/571319/Scene1/2'>sheet</scene> was colored as blue, respectively. Most <scene name='57/571319/Scene1/3'>conserved area</scene> ,which is dark red color, was buried inside of the protein.

Interleukin-1 beta: Difference between revisions

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@@ Line 8: / Line 8: @@
 '''THREE-DIMENSIONAL STRUCTURE OF IL-1β'''
-"The molecule resembles a conical barrel with a shallow open face on one end and a closed face on the other. The molecule contains 12 antiparallel 13-strands, where six of these (131, 14, 15, 18, 19, and 1312) constitute an antiparallel 1 barrel. The overall structure of the molecule consists of three similar fragments (Fl, F2, F3), each containing two pairs of 1 strands. Three pairs of 1 strands (one pair from each of the fragments) form the six stranded barrel; the other three pairs cover one end of the barrel, referred to as the "closed end." The amino and carboxy termini are close to each other at the "open end" of the barrel. The molecule has internal pseudo threefold symmetry, with each subunit (Fl, F2, F3) having a 13L13 motif. There are five 1-hairpins in this molecule, two of them in the open end and three at the closed end. 24 hydrophobic side chains line the inner surface of the barrel and both the ends of the barrel have concentrations of exposed polar residues."[4]
+The molecule contains 12 antiparallel β-strands. The molecule has internal pseudo threefold symmetry with the molecule represents a conical barrel with a shallow open face on one end and a closed face on the other. The amino and carboxy termini are close to each other at the "open end" of the barrel. There are five 1-hairpins in this molecule, two of them in the open end and three at the closed end. 24 hydrophobic side chains line the inner surface of the barrel and both the ends of the barrel have concentrations of exposed polar residues. More detail structure information could be found in reference[4].
 <scene name='57/571319/Scene1/1'>Human Interleukin-1 beta</scene> are present in the 3D structure. In the picture we could see <scene name='57/571319/Scene1/2'>helix</scene> was colored as purple and <scene name='57/571319/Scene1/2'>sheet</scene> was colored as blue, respectively. Most <scene name='57/571319/Scene1/3'>conserved area</scene> ,which is dark red color, was buried inside of the protein.