Interleukin-1 beta: Difference between revisions
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== Interleukin-1 beta(IL-1β) == | == Interleukin-1 beta(IL-1β) == | ||
<Structure load='9ilb' size='400' frame='true' align='right' caption='HUMAN INTERLEUKIN-1 | <Structure load='9ilb' size='400' frame='true' align='right' caption='HUMAN INTERLEUKIN-1 β (PDB code [[9ilb]])' scene='57/571319/Scene1/1' /> | ||
IL-1β along with IL-1α cytokines secreted from local inflammatory cells, are belong to IL-1 family.[1] The former is dominate (90% of Interleukin-1) and the two cytokines could be distinguished by the cells with which they interact. IL-1β precursor(31KDa) need to be activated by protease (convertase or IL-1β converting enzyme[2]) to form IL-1 active species(17KDa)[3]. The active mature IL-1 cytokines could mediate a large range of biological activities such as innate and adaptive immunity as well as bio-components of the acute phase reaction, including the febrile response, secretion of adrenocorticotropic hormone (ACIH), and the synthesis of [http://en.wikipedia.org/wiki/Acute-phase_protein acute phase proteins]. | IL-1β along with IL-1α cytokines secreted from local inflammatory cells, are belong to IL-1 family.[1] The former is dominate (90% of Interleukin-1) and the two cytokines could be distinguished by the cells with which they interact. IL-1β precursor(31KDa) need to be activated by protease (convertase or IL-1β converting enzyme[2]) to form IL-1 active species(17KDa)[3]. The active mature IL-1 cytokines could mediate a large range of biological activities such as innate and adaptive immunity as well as bio-components of the acute phase reaction, including the febrile response, secretion of adrenocorticotropic hormone (ACIH), and the synthesis of [http://en.wikipedia.org/wiki/Acute-phase_protein acute phase proteins]. | ||
