Mur ligase: Difference between revisions
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[[1e0d]] – EcMurD – ''Escherichia coli'' <br /> | [[1e0d]] – EcMurD – ''Escherichia coli'' <br /> | ||
[[3lk7]] – MurD – ''Streptococcus agalactiae''<br /> | [[3lk7]] – MurD – ''Streptococcus agalactiae''<br /> | ||
[[4bub]] – TmMurD – ''Thermotoga maritima''<br /> | |||
'''MurD complex with ligand''' | '''MurD complex with ligand''' | ||
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[[3uag]] – EcMurD + UMA + ADP + Mn<br /> | [[3uag]] – EcMurD + UMA + ADP + Mn<br /> | ||
[[4uag]] – EcMurD + UAG<br /> | [[4uag]] – EcMurD + UAG<br /> | ||
[[4bub]] – TmMurD + ADP <br /> | |||
'''MurD complex with inhibitor''' | '''MurD complex with inhibitor''' | ||
Revision as of 08:26, 30 March 2014
<StructureSection load='2jfg' size='350' side='right' caption='Structure of MurD ligase complex with UMA (stick model), ADP (stick model) and sulfate (PDB entry 2jfg)' scene=>
MurD ligase or UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase catalyzes the conversion of UDP-N-acetylmuramoyl-L-alanine (UMA), D-glutamate and ATP to UDP-N-acetylmuramoyl-L-alanine-D-glutamate and ADP. MurD is part of the bacterial peptidoglycan synthesis pathway.
3D Structures of MurD ligase
Updated on 30-March-2014
1e0d – EcMurD – Escherichia coli
3lk7 – MurD – Streptococcus agalactiae
4bub – TmMurD – Thermotoga maritima
MurD complex with ligand
1uag, 1eeh – EcMurD + UMA
2jfg – EcMurD + UMA + ADP
2uag – EcMurD + UMA + ADP + Mg
3uag – EcMurD + UMA + ADP + Mn
4uag – EcMurD + UAG
4bub – TmMurD + ADP
MurD complex with inhibitor
2jff, 2jfh, 2uuo, 2uup, 2vtd, 2vte, 2xpc – EcMurD + sulfonamide inhibitor
2wjp – EcMurD + rhodanine inhibitor
2x5o, 2y68, 2y66, 2y67, 2y1o – EcMurD + thiazolidine inhibitor
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman
