3wlu: Difference between revisions
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''' | ==Crystal Structure of human galectin-9 NCRD with Selenolactose== | ||
<StructureSection load='3wlu' size='340' side='right' caption='[[3wlu]], [[Resolution|resolution]] 1.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3wlu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WLU FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LSE:2-(TRIMETHYLSILYL)ETHYL+4-O-BETA-D-GALACTOPYRANOSYL-6-SE-METHYL-6-SELENO-BETA-D-GLUCOPYRANOSIDE'>LSE</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2eak|2eak]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wlu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wlu RCSB], [http://www.ebi.ac.uk/pdbsum/3wlu PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Seleno-lactoses have been successfully synthesized as candidates for mimicking carbohydrate ligands for human galectin-9 N-terminal carbohydrate recognition domain (NCRD). Selenium was introduced into the mono- or di-saccharides using p-methylselenobenzoic anhydride (Tol2Se) as a novel selenating reagent. The TolSe-substituted monosaccharides were converted into selenoglycosyl donors or acceptors, which were reacted with coupling partners to afford seleno-lactoses. The seleno-lactoses were converted to the target compounds. The structure of human galectin-9 NCRD co-crystallized with 6-MeSe-lactose was determined with single/multi-wavelength anomalous dispersion (SAD/MAD) phasing and was similar to that of the co-crystal with natural lactose. | |||
Expanded potential of seleno-carbohydrates as a molecular tool for X-ray structural determination of a carbohydrate-protein complex with single/multi-wavelength anomalous dispersion phasing.,Suzuki T, Makyio H, Ando H, Komura N, Menjo M, Yamada Y, Imamura A, Ishida H, Wakatsuki S, Kato R, Kiso M Bioorg Med Chem. 2014 Apr 1;22(7):2090-101. doi: 10.1016/j.bmc.2014.02.023. Epub , 2014 Feb 25. PMID:24631362<ref>PMID:24631362</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Ando, H.]] | |||
[[Category: Ishida, H.]] | |||
[[Category: Kato, R.]] | |||
[[Category: Kiso, M.]] | |||
[[Category: Makyio, H.]] | |||
[[Category: Suzuki, T.]] | |||
[[Category: Wakatsuki, S.]] | |||
[[Category: Yamada, Y.]] | |||
[[Category: Beta sandwich]] | |||
[[Category: Carbohydrate binding]] | |||
[[Category: Galectin]] | |||
[[Category: Selenolactose]] | |||
[[Category: Sugar binding protein]] | |||
Revision as of 08:47, 5 November 2014
Crystal Structure of human galectin-9 NCRD with Selenolactose
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