4lv4: Difference between revisions
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' | {{STRUCTURE_4lv4| PDB=4lv4 | SCENE= }} | ||
===A noncompetitive inhibitor for M. tuberculosis's class IIa fructose 1,6-bisphosphate aldolase=== | |||
{{ABSTRACT_PUBMED_24325645}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ALF_MYCTU ALF_MYCTU]] Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis (By similarity). | |||
==About this Structure== | |||
[[4lv4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LV4 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024325645</ref><references group="xtra"/><references/> | |||
[[Category: Fructose-bisphosphate aldolase]] | |||
[[Category: Capodagli, G C.]] | |||
[[Category: Pegan, S D.]] | |||
[[Category: 6-bisphosphate aldolase]] | |||
[[Category: 8-hydroxyquinoline-2-carboxylic acid]] | |||
[[Category: Aldol condensation]] | |||
[[Category: Class ii fructose-1]] | |||
[[Category: Dihydroxyacetone]] | |||
[[Category: Glyceraldehyde-3-phosphate]] | |||
[[Category: Glycolysis]] | |||
[[Category: Lyase]] | |||
[[Category: Lyase-lyase inhibitor complex]] | |||
[[Category: Metal-binding]] | |||
[[Category: Mycobacterium tuberculosis]] | |||
[[Category: Zinc enzyme]] | |||
Revision as of 10:32, 8 January 2014
A noncompetitive inhibitor for M. tuberculosis's class IIa fructose 1,6-bisphosphate aldolase
Template:ABSTRACT PUBMED 24325645
Function
[ALF_MYCTU] Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis (By similarity).
About this Structure
4lv4 is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Capodagli GC, Sedhom WG, Jackson M, Ahrendt KA, Pegan SD. A Noncompetitive Inhibitor for Mycobacterium tuberculosis's Class IIa Fructose 1,6-Bisphosphate Aldolase. Biochemistry. 2013 Dec 24. PMID:24325645 doi:https://dx.doi.org/10.1021/bi401022b
