4nih: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4nih|  PDB=4nih  |  SCENE=  }}
===Crystal structure of AlkB E136L mutant protein with cofactors bound to dsDNA containing m6A/A===
{{ABSTRACT_PUBMED_24596302}}


The entry 4nih is ON HOLD until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/ALKB_ECOLI ALKB_ECOLI]] Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents).<ref>PMID:12226668</ref> <ref>PMID:12594517</ref> <ref>PMID:16482161</ref> <ref>PMID:19706517</ref> <ref>PMID:21068844</ref> <ref>PMID:20084272</ref>  


Authors: Yi, C.Q., Zhu, C.X.
==About this Structure==
[[4nih]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NIH OCA].  


Description: Crystal structure of AlkB E136L mutant protein with cofactors bound to dsDNA containing m6A/A
==Reference==
<ref group="xtra">PMID:024596302</ref><references group="xtra"/><references/>
[[Category: DNA oxidative demethylase]]
[[Category: Yi, C Q.]]
[[Category: Zhu, C X.]]
[[Category: 2-kg]]
[[Category: Dna/rna demethylation repair]]
[[Category: Dna/rna direct repair]]
[[Category: Jelly-roll fold]]
[[Category: Oxidoreductase-dna complex]]
Retrieved from "https://proteopedia.org/4nih"