4ntj: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4ntj|  PDB=4ntj  |  SCENE=  }}
===Structure of the human P2Y12 receptor in complex with an antithrombotic drug===


The entry 4ntj is ON HOLD
==Disease==
[[http://www.uniprot.org/uniprot/P2Y12_HUMAN P2Y12_HUMAN]] Resistance to clopidogrel in myocardial infarction, cerebrovascular accident, oblitering arteriopathy of the lower limbs;P2Y12 defect. The disease is caused by mutations affecting the gene represented in this entry.


Authors: Zhang, K., Zhang, J., Gao, Z.-G., Zhang, D., Zhu, L., Han, G.W., Moss, S.M., Paoletta, S., Kiselev, E., Lu, W., Fenalti, G., Zhang, W., Muller, C.E., Yang, H., Jiang, H., Cherezov, V., Katritch, V., Jacobson, K.A., Stevens, R.C., Wu, B., Zhao, Q., GPCR Network (GPCR)
==Function==
[[http://www.uniprot.org/uniprot/P2Y12_HUMAN P2Y12_HUMAN]] Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelet aggregation.  


Description: Structure of the human P2Y12 receptor in complex with an antithrombotic drug
==About this Structure==
[[4ntj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NTJ OCA].
[[Category: Cherezov, V.]]
[[Category: Fenalti, G.]]
[[Category: GPCR, GPCR Network.]]
[[Category: Gao, Z G.]]
[[Category: Han, G W.]]
[[Category: Jacobson, K A.]]
[[Category: Jiang, H.]]
[[Category: Katritch, V.]]
[[Category: Kiselev, E.]]
[[Category: Lu, W.]]
[[Category: Moss, S M.]]
[[Category: Muller, C E.]]
[[Category: Paoletta, S.]]
[[Category: Stevens, R C.]]
[[Category: Wu, B.]]
[[Category: Yang, H.]]
[[Category: Zhang, D.]]
[[Category: Zhang, J.]]
[[Category: Zhang, K.]]
[[Category: Zhang, W.]]
[[Category: Zhao, Q.]]
[[Category: Zhu, L.]]
[[Category: Antithrombotic drug]]
[[Category: Gpcr]]
[[Category: Gpcr network]]
[[Category: Human p2y12 receptor]]
[[Category: Lipidic cubic phase]]
[[Category: Membrane]]
[[Category: Membrane protein]]
[[Category: Psi-biology]]
[[Category: Signaling protein]]
[[Category: Structural genomic]]

Revision as of 09:38, 26 March 2014

Template:STRUCTURE 4ntj

Structure of the human P2Y12 receptor in complex with an antithrombotic drug

Disease

[P2Y12_HUMAN] Resistance to clopidogrel in myocardial infarction, cerebrovascular accident, oblitering arteriopathy of the lower limbs;P2Y12 defect. The disease is caused by mutations affecting the gene represented in this entry.

Function

[P2Y12_HUMAN] Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelet aggregation.

About this Structure

4ntj is a 1 chain structure. Full crystallographic information is available from OCA.

Proteopedia Page Contributors and Editors (what is this?)

OCA

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