2uzu: Difference between revisions

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[[Image:2uzu.jpg|left|200px]]~~<br /><applet load~~="2uzu~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:2uzu.jpg|left|200px]]

~~caption="~~2uzu, resolution 2.4Å" />

'''PKA STRUCTURES OF INDAZOLE-PYRIDINE SERIES OF AKT INHIBITORS'''~~<br />~~

{{Structure

|PDB= 2uzu |SIZE=350|CAPTION= <scene name='initialview01'>2uzu</scene>, resolution 2.4Å

|SITE= <scene name='pdbsite=AC1:L20+Binding+Site+For+Chain+E'>AC1</scene>

|LIGAND= <scene name='pdbligand=L20:(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE'>L20</scene>

|ACTIVITY= [http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11]

|GENE=

}}

'''PKA STRUCTURES OF INDAZOLE-PYRIDINE SERIES OF AKT INHIBITORS'''

==Overview==

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==About this Structure==

2UZU is a [~~http://en.wikipedia.org/wiki/Protein_complex~~ Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=L20:'>L20</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] Known structural/functional Site: <scene name='pdbsite=AC1:L20+Binding+Site+For+Chain+E'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZU OCA].

2UZU is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZU OCA].

==Reference==

Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase b/akt inhibitors with reduced hypotension., Zhu GD, Gandhi VB, Gong J, Thomas S, Woods KW, Song X, Li T, Diebold RB, Luo Y, Liu X, Guan R, Klinghofer V, Johnson EF, Bouska J, Olson A, Marsh KC, Stoll VS, Mamo M, Polakowski J, Campbell TJ, Martin RL, Gintant GA, Penning TD, Li Q, Rosenberg SH, Giranda VL, J Med Chem. 2007 Jun 28;50(13):2990-3003. Epub 2007 May 25. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~17523610 17523610]

Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase b/akt inhibitors with reduced hypotension., Zhu GD, Gandhi VB, Gong J, Thomas S, Woods KW, Song X, Li T, Diebold RB, Luo Y, Liu X, Guan R, Klinghofer V, Johnson EF, Bouska J, Olson A, Marsh KC, Stoll VS, Mamo M, Polakowski J, Campbell TJ, Martin RL, Gintant GA, Penning TD, Li Q, Rosenberg SH, Giranda VL, J Med Chem. 2007 Jun 28;50(13):2990-3003. Epub 2007 May 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17523610 17523610]

[[Category: Bos taurus]]

[[Category: Protein complex]]

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[[Category: Zhu, G D.]]

[[Category: L20]]

[[Category: akt ~~inhibitors~~]]

[[Category: akt inhibitor]]

[[Category: atp-binding]]

[[Category: camp]]

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[[Category: nucleotide-binding]]

[[Category: phosphorylation]]

[[Category: protein kinase a]]

[[Category: protein kinase some]]

[[Category: protein kinase inhibitor]]

[[Category: serine/threonine-protein kinase]]

[[Category: transferase]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:41:44 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2uzu.jpg|left|200px]]<br /><applet load="2uzu" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2uzu.jpg|left|200px]]
-caption="2uzu, resolution 2.4&Aring;" />
-'''PKA STRUCTURES OF INDAZOLE-PYRIDINE SERIES OF AKT INHIBITORS'''<br />
+ {{Structure
+|PDB= 2uzu |SIZE=350|CAPTION= <scene name='initialview01'>2uzu</scene>, resolution 2.4&Aring;
+|SITE= <scene name='pdbsite=AC1:L20+Binding+Site+For+Chain+E'>AC1</scene>
+|LIGAND= <scene name='pdbligand=L20:(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE'>L20</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11]
+|GENE=
+}}
+'''PKA STRUCTURES OF INDAZOLE-PYRIDINE SERIES OF AKT INHIBITORS'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-UZU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=L20:'>L20</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] Known structural/functional Site: <scene name='pdbsite=AC1:L20+Binding+Site+For+Chain+E'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZU OCA].
+UZU is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZU OCA].
 ==Reference==
-Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase b/akt inhibitors with reduced hypotension., Zhu GD, Gandhi VB, Gong J, Thomas S, Woods KW, Song X, Li T, Diebold RB, Luo Y, Liu X, Guan R, Klinghofer V, Johnson EF, Bouska J, Olson A, Marsh KC, Stoll VS, Mamo M, Polakowski J, Campbell TJ, Martin RL, Gintant GA, Penning TD, Li Q, Rosenberg SH, Giranda VL, J Med Chem. 2007 Jun 28;50(13):2990-3003. Epub 2007 May 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17523610 17523610]
+Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase b/akt inhibitors with reduced hypotension., Zhu GD, Gandhi VB, Gong J, Thomas S, Woods KW, Song X, Li T, Diebold RB, Luo Y, Liu X, Guan R, Klinghofer V, Johnson EF, Bouska J, Olson A, Marsh KC, Stoll VS, Mamo M, Polakowski J, Campbell TJ, Martin RL, Gintant GA, Penning TD, Li Q, Rosenberg SH, Giranda VL, J Med Chem. 2007 Jun 28;50(13):2990-3003. Epub 2007 May 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17523610 17523610]
 [[Category: Bos taurus]]
 [[Category: Protein complex]]
@@ Line 39: / Line 48: @@
 [[Category: Zhu, G D.]]
 [[Category: L20]]
-[[Category: akt inhibitors]]
+[[Category: akt inhibitor]]
 [[Category: atp-binding]]
 [[Category: camp]]
@@ Line 48: / Line 57: @@
 [[Category: nucleotide-binding]]
 [[Category: phosphorylation]]
-[[Category: protein kinase a]]
+[[Category: protein kinase some]]
 [[Category: protein kinase inhibitor]]
 [[Category: serine/threonine-protein kinase]]
 [[Category: transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:51:57 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:41:44 2008''