4o38: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4o38|  PDB=4o38  |  SCENE=  }}
===Crystal structure of the human cyclin G associated kinase (GAK)===


The entry 4o38 is ON HOLD
==Function==
[[http://www.uniprot.org/uniprot/GAK_HUMAN GAK_HUMAN]] Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.<ref>PMID:10625686</ref> 


Authors: Zhang, R., Hatzos-Skintges, C., Weger, A., Chaikuad, A., Eswaran, J., Fedorov, O., King, O., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S., Joachimiak, A., Structural Genomics Consortium (SGC)
==About this Structure==
[[4o38]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ll6 3ll6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O38 OCA].  


Description: Crystal structure of the human cyclin G associated kinase (GAK)
==Reference==
<references group="xtra"/><references/>
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Arrowsmith, C H.]]
[[Category: Bountra, C.]]
[[Category: Chaikuad, A.]]
[[Category: Delft, F von.]]
[[Category: Edwards, A.]]
[[Category: Eswaran, J.]]
[[Category: Fedorov, O.]]
[[Category: Hatzos-Skintges, C.]]
[[Category: Joachimiak, A.]]
[[Category: King, O.]]
[[Category: Knapp, S.]]
[[Category: MCSG, Midwest Center for Structural Genomics.]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Weger, A.]]
[[Category: Weigelt, J.]]
[[Category: Zhang, R.]]
[[Category: Atp-binding]]
[[Category: Cell cycle]]
[[Category: Cell junction]]
[[Category: Clathrine]]
[[Category: Cyclin g]]
[[Category: Golgi apparatus]]
[[Category: Kinase]]
[[Category: Mcsg]]
[[Category: Membrane trafficking]]
[[Category: Midwest center for structural genomic]]
[[Category: Nucleotide-binding]]
[[Category: P53]]
[[Category: Phosphoprotein]]
[[Category: Protein kinase]]
[[Category: Protein structure initiative]]
[[Category: Psi-2]]
[[Category: Serine/threonine kinase]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Transferase]]

Revision as of 12:04, 1 January 2014

Template:STRUCTURE 4o38

Crystal structure of the human cyclin G associated kinase (GAK)

Function

[GAK_HUMAN] Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.[1]

About this Structure

4o38 is a 2 chain structure. This structure supersedes the now removed PDB entry 3ll6. Full crystallographic information is available from OCA.

Reference

  1. ↑ Greener T, Zhao X, Nojima H, Eisenberg E, Greene LE. Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from non-neuronal cells. J Biol Chem. 2000 Jan 14;275(2):1365-70. PMID:10625686

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