4o3m: Difference between revisions
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' | {{STRUCTURE_4o3m| PDB=4o3m | SCENE= }} | ||
===Ternary complex of Bloom's syndrome helicase=== | |||
The entry | ==Disease== | ||
[[http://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN]] Bloom syndrome. The disease is caused by mutations affecting the gene represented in this entry. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN]] Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE).<ref>PMID:9388193</ref> <ref>PMID:12019152</ref> <ref>PMID:21325134</ref> <ref>PMID:23509288</ref> | |||
==About this Structure== | |||
[[4o3m]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O3M OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: DNA helicase]] | |||
[[Category: Bertrand, J.]] | |||
[[Category: Swan, M K.]] | |||
[[Category: Helicase]] | |||
[[Category: Hydrolase-dna complex]] | |||
[[Category: Winged helix]] | |||
