2v11: Difference between revisions

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[[Image:2v11.gif|left|200px]]<br /><applet load="2v11" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2v11.gif|left|200px]]
caption="2v11, resolution 3.1&Aring;" />
 
'''CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 6'''<br />
{{Structure
|PDB= 2v11 |SIZE=350|CAPTION= <scene name='initialview01'>2v11</scene>, resolution 3.1&Aring;
|SITE= <scene name='pdbsite=AC1:C80+Binding+Site+For+Chain+O'>AC1</scene>
|LIGAND= <scene name='pdbligand=C80:(2S,4S,5R,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXOOCTYL 1-BENZYL-1H-INDOLE-3-CARBOXYLATE'>C80</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15]
|GENE=
}}
 
'''CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 6'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2V11 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=C80:'>C80</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] Known structural/functional Site: <scene name='pdbsite=AC1:C80+Binding+Site+For+Chain+O'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V11 OCA].  
2V11 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V11 OCA].  


==Reference==
==Reference==
Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin., Rahuel J, Rasetti V, Maibaum J, Rueger H, Goschke R, Cohen NC, Stutz S, Cumin F, Fuhrer W, Wood JM, Grutter MG, Chem Biol. 2000 Jul;7(7):493-504. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10903938 10903938]
Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin., Rahuel J, Rasetti V, Maibaum J, Rueger H, Goschke R, Cohen NC, Stutz S, Cumin F, Fuhrer W, Wood JM, Grutter MG, Chem Biol. 2000 Jul;7(7):493-504. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10903938 10903938]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Renin]]
[[Category: Renin]]
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[[Category: alternative splicing]]
[[Category: alternative splicing]]
[[Category: aspartyl protease]]
[[Category: aspartyl protease]]
[[Category: cleavage on pair of basic residues]]
[[Category: cleavage on pair of basic residue]]
[[Category: glycoprotein]]
[[Category: glycoprotein]]
[[Category: hydrolase]]
[[Category: hydrolase]]
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[[Category: zymogen]]
[[Category: zymogen]]


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