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{{STRUCTURE_4iio|  PDB=4iio  |  SCENE=  }}
==Crystal Structure of the Second SH3 Domain of ITSN2 Bound with a Synthetic Peptide==
===Crystal Structure of the Second SH3 Domain of ITSN2 Bound with a Synthetic Peptide===
<StructureSection load='4iio' size='340' side='right' caption='[[4iio]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[4iio]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IIO FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/ITSN2_HUMAN ITSN2_HUMAN]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).<ref>PMID:19458185</ref> <ref>PMID:22648170</ref>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
 
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
==About this Structure==
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ITSN2, KIAA1256, SH3D1B, SWAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
[[4iio]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIO OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iio OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iio RCSB], [http://www.ebi.ac.uk/pdbsum/4iio PDBsum]</span></td></tr>
 
</table>
==Reference==
__TOC__
<references group="xtra"/><references/>
</StructureSection>
[[Category: Arrowsmith, C H.]]
[[Category: Human]]
[[Category: Bountra, C.]]
[[Category: Arrowsmith, C H]]
[[Category: Dong, A.]]
[[Category: Bountra, C]]
[[Category: Edwards, A M.]]
[[Category: Dong, A]]
[[Category: Gu, J.]]
[[Category: Edwards, A M]]
[[Category: Guan, X.]]
[[Category: Gu, J]]
[[Category: Huang, H.]]
[[Category: Guan, X]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Huang, H]]
[[Category: Sidhu, S.]]
[[Category: Structural genomic]]
[[Category: Tempel, W.]]
[[Category: Sidhu, S]]
[[Category: Tong, Y.]]
[[Category: Tempel, W]]
[[Category: Tong, Y]]
[[Category: Endocytosis]]
[[Category: Endocytosis]]
[[Category: Itsn2]]
[[Category: Itsn2]]
Line 26: Line 27:
[[Category: Sgc]]
[[Category: Sgc]]
[[Category: Sh3 domain]]
[[Category: Sh3 domain]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Synthetic peptide]]
[[Category: Synthetic peptide]]

Revision as of 18:36, 21 December 2014

Crystal Structure of the Second SH3 Domain of ITSN2 Bound with a Synthetic Peptide

4iio, resolution 1.70Å

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